5,996 Result(s)

Article

Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study

Neoadjuvant chemoradiotherapy has been the standard practice for patients with locally advanced rectal cancer. However, the treatment response varies greatly among individuals, how to select the optimal candid...

Junhao Zhang, Ruiqing Liu, Xujian Wang… in Journal of Cancer Research and Clinical On… (2024)

Article

Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma

Patients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed to dissect the potential mechanisms underlying poor response to ICBs and explo...

Bao-Ye Sun, Dai Zhang, Wei Gan, **g-Fang Wu… in Journal of Cancer Research and Clinical On… (2024)

Article

LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway

Long noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with RNAs. Among these, lncRNA ZFAS1 has been implicated in oncogenic roles ...

Baoyang Luo, Lin Zhuang, Ju Huang… in Journal of Cancer Research and Clinical On… (2024)

Article

An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective

To explore the role of GAB2 in pan-cancer based on bioinformatics analysis.

Yi Yin, Yong Li, Yaoyang Zhang, Qiucheng Jia, Huiming Tang… in Discover Oncology (2024)

Article

Effect of dipeptidyl peptidase-4 inhibitors on tumor necrosis factor alpha levels in patients with type 2 diabetes mellitus

Dipeptidyl peptidase-4 inhibitors (DPP-4i) served as oral antidiabetic agents for treatment of type 2 diabetes mellitus (T2DM). Although an action on glucose homeostasis was identified, no well-rounded illustr...

Lijia Zhao, Jie Meng, Xueyan Bai, Donglei Zhang… in European Journal of Medical Research (2024)

Article

MICAL1 promotes the proliferation in acute myeloid leukemia and is associated with clinical prognosis and immune infiltration

Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has a poor prognosis and a high rate of relapse. Dysregulated metabolism plays an important role in AML progression. This ...

Yinsen Song, Zhenzhen Yang, Na Gao, Bojun Zhang in Discover Oncology (2024)

Article

Correction: Association of α-HBDH levels with the severity and recurrence after acute ischemic stroke

Qiang Wang, Ting Deng, Yuanyuan **e, Haitao Lu… in European Journal of Medical Research (2024)

Article

Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression

Cholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1 (DCLK1) promotes a variety of malignant cancers in their progression. Targ...

Ziwei Liang, Yang Ge, Jianjian Li… in Journal of Cancer Research and Clinical On… (2024)

Article

ZBTB7A regulates LncRNA HOTAIR-mediated ELAVL1/SOX17 axis to inhibit malignancy and angiogenesis in endometrial carcinoma

Endometrial cancer (EC) is the sixth most frequent cancer in women worldwide and has higher fatality rates. The pathophysiology of EC is complex, and there are currently no reliable methods for diagnosing and ...

**ao-Hui Zhang, Shu-Wei Wu, Yi-Fan Feng… in Journal of Cancer Research and Clinical On… (2024)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Multi-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis

Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms. These conditions share overlap** clinical presentations; howe...

Anqi Zhang, Ting Sun, Dandan Yu, Rongfeng Fu… in Clinical and Experimental Medicine (2024)

Article

Efficacy and safety of tislelizumab plus bacillus-calmette guérin with or without chemotherapy as a bladder-sparing treatment for high-risk non-muscle-invasive bladder urothelial cancer: a real-world study

Despite adequate transurethral resection of the bladder tumor (TURBT) followed by intravesical bacillus-calmette guérin (BCG), high-risk non-muscle-invasive bladder cancer (HR-NMIBC) is associated with high ra...

Peng Wu, Wei Zhang, Wei Hu, Yitong Cao, Jia Wang, Lei Yu in Discover Oncology (2024)

Article

Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma

The evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating advanced hepatocellular carcinoma (HCC) is limited. This study aimed to compare the tre...

Jianfei Wu, Xuefeng Bai, Guodong Yu… in Journal of Cancer Research and Clinical On… (2024)

Article

Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia

T(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis. However, recent small case reports suggest the limited effectiveness o...

Zhao Yin, Zurong Yao, Dandan Chen, Yu Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Deciphering glutamine metabolism patterns for malignancy and tumor microenvironment in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer characterized by metabolic reprogramming. Glutamine metabolism is pivotal in metabolic reprogramming, contributing to the sig...

Gengrun Wu, Teng Li, Yuanbiao Chen, Shiqi Ye… in Clinical and Experimental Medicine (2024)

Article

Alopecia areata following COVID-19 vaccine: a systematic review

To date, multiple cases of adverse reactions to COVID-19 vaccines have been reported worldwide. Alopecia areata (AA) is an uncommon type of adverse reaction reported in some articles and has a significant soci...

Yunxia Zhu, **aoliang Ouyang, Deng Zhang… in European Journal of Medical Research (2024)

Article

M2-type tumor-associated macrophages upregulated PD-L1 expression in cervical cancer via the PI3K/AKT pathway

PD-1/PD-L1 inhibitors have become a promising therapy. However, the response rate is lower than 30% in patients with cervical cancer (CC), which is related to immunosuppressive components in tumor microenviron...

Fan Guo, Weina Kong, Dewei Li, Gang Zhao… in European Journal of Medical Research (2024)

Article

lncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin

In this study, we investigated the role of the newly discovered lncRNA FLJ20021 in laryngeal cancer (LC) and its resistance to cisplatin treatment. We initially observed elevated lncRNA FLJ20021 levels in cisp...

**aoyan Yin, Haizhong Zhang, **gmiao Wang, Yanrui Bian, Qiao**g Jia… in Discover Oncology (2024)

Article

Global research states and trends of micro RNA in irritable bowel syndrome: a bibliometric analysis

Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder, but its diagnosis and treatment remain obscure. Non-coding RNAs (ncRNAs), as potential biomarkers, have attracted increasing attent...

Hongxiu Chen, Zhifang Xu, Honggang Zhao, Jiazhen Cao… in Clinical and Experimental Medicine (2024)