1,483 Result(s)

Article

Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas

The clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale, population-based study aimed to comprehensively outline these traits and construct ...

Tao Chang, Rui Zhang, Jiahao Gan, Yuan Yang, Yanhui Liu, Yan Ju, **aodong Niu… in BMC Cancer (2024)

Article

Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma

Patients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed to dissect the potential mechanisms underlying poor response to ICBs and explo...

Bao-Ye Sun, Dai Zhang, Wei Gan, **g-Fang Wu… in Journal of Cancer Research and Clinical On… (2024)

Article

Author Correction: LINE-1 transcription activates long-range gene expression

**ufeng Li, Luyao Bie, Yang Wang, Yaqiang Hong, Ziqiang Zhou, Yiming Fan… in Nature Genetics (2024)

Article

Unbiasedly decoding the tumor microenvironment with single-cell multiomics analysis in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) of PDAC has propelled the developme...

Yifan Fu, **xin Tao, Tao Liu, Yueze Liu, Jiangdong Qiu, Dan Su… in Molecular Cancer (2024)

Article

A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression

The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development of various human cancers by modifying diverse biological functions. However, the precise molecular mechani...

Weiwei Liu, Zhao Ding, Ye Tao, Shixian Liu, Maoyu Jiang, Fangzheng Yi… in Molecular Cancer (2024)

Article

Synthetic CT generation for pelvic cases based on deep learning in multi-center datasets

To investigate the feasibility of synthesizing computed tomography (CT) images from magnetic resonance (MR) images in multi-center datasets using generative adversarial networks (GANs) for rectal cancer MR-onl...

**anan Li, Lecheng Jia, Fengyu Lin, Fan Chai, Tao Liu, Wei Zhang… in Radiation Oncology (2024)

Article

Development and validation of an automated Tomotherapy planning method for cervical cancer

This study aimed to develop an automated Tomotherapy (TOMO) planning method for cervical cancer treatment, and to validate its feasibility and effectiveness.

Feiru Han, Yi Xue, Sheng Huang, Tong Lu, Yining Yang, Yuanjie Cao… in Radiation Oncology (2024)

Article

Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial

Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This...

Jianjun Qin, Liyan Xue, Anlin Hao, **aofeng Guo, Tao Jiang, Yunfeng Ni… in Nature Medicine (2024)

Article

Activation of lncRNA DANCR by H3K27 acetylation regulates proliferation of colorectal cancer cells

The long noncoding DANCR functions as a tumor oncogene in many cancers, including colorectal cancer (CRC). However, the molecular mechanism of DANCR in CRC has not been explored. This study probed the function...

Yue Han, Ti-Dong Shan, Hai-Tao Huang, Ming-Quan Song, Li Chen, Qian Li in Discover Oncology (2024)

Article

MRI features and tumor-infiltrating CD8 + T cells-based nomogram for predicting meningioma recurrence risk

This study was based on MRI features and number of tumor-infiltrating CD8 + T cells in post-operative pathology, in predicting meningioma recurrence risk.

Tao Han, **anwang Liu, Changyou Long, Shenglin Li, Fengyu Zhou… in Cancer Imaging (2024)

Article

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...

Yuzheng Zhou, Zongpeng Chen, Sijie Liu… in Signal Transduction and Targeted Therapy (2024)

Article

WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis

Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not achieved satisfactory outcomes, recently, targeted therapies for glioma have...

Tao Yan, Qing Jiang, Guangpu Ni, Haofeng Ma, Yun Meng… in Cancer Cell International (2024)

Article

Screening of potential hub genes involved in Kidney Wilms tumor via bioinformatics analysis and experimental validation

Wilms tumor (WT) is the most common pediatric embryonal tumor. Improving patient outcomes requires advances in understanding and targeting the multiple genes and cellular control pathways, but its pathogenesis...

Qiang Zeng, Tingting Liu, Lilu Qin, Chen Wang, Guangbei Peng, Zhong Liu… in BMC Cancer (2024)

Article

Inhibition of ABI2 ubiquitination-dependent degradation suppresses TNBC cell growth via down-regulating PI3K/Akt signaling pathway

Triple negative breast cancer (TNBC) is a type of cancer that lacks receptor expression and has complex molecular mechanisms. Recent evidence shows that the ubiquitin-protease system is closely related to TNBC...

Linlin Lv, Shu**g Li, Jie Kang, Yulin Li, Nannan Zhao… in Cancer Cell International (2024)

Article

Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2^V617F-induced myeloproliferative neoplasms

Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, **bing Zhu, Ailin Zhao… in Blood Cancer Journal (2024)

Article

cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer

Cancer cells frequently evolve necroptotic resistance to overcome various survival stress during tumorigenesis. However, we have previously showed that necroptosis is widespread in head and neck squamous cell ...

**gyuan Li, Jun Tan, Tao Wang, Shan Yu… in Experimental Hematology & Oncology (2024)

Article

Enhancing hepatocellular carcinoma management: prognostic value of integrated CCL17, CCR4, CD73, and HHLA2 expression analysis

Hepatocellular carcinoma (HCC) is a critical global health concern, with existing treatments benefiting only a minority of patients. Recent findings implicate the chemokine ligand 17 (CCL17) and its receptor C...

Wei Gan, Bao-Ye Sun, Zhang-Fu Yang, Cheng Ye… in Journal of Cancer Research and Clinical On… (2024)

Article

A novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension

Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...

Jia-zhou Ye, Hua-ze Lu, Can Zeng, Guo Lei, **ao-bo Wang, Jie Chen, Tao Bai… in BMC Cancer (2024)

Article

DNAJC1 facilitates glioblastoma progression by promoting extracellular matrix reorganization and macrophage infiltration

Glioblastoma (GBM) is a high-grade and heterogeneous subtype of glioma that presents a substantial challenge to human health, characterized by a poor prognosis and low survival rates. Despite its known involve...

Han Zhang, Wen**g Zheng, Xu Chen, Longqi Sa… in Journal of Cancer Research and Clinical On… (2024)

Article

Correlation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis

The role of hemoglobin (HGB) in common malignant tumors remains unclear.

Guo-Sheng Li, Tao Huang, **g-**ao Li, Jun Liu, **ang Gao, Nuo Yang… in BMC Cancer (2024)