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Article
Topic-aware cosine graph convolutional neural network for short text classification
Graph Convolutional Network (GCN) has been extensively studied in the task of short text classification (STC), utilizing global graphs that incorporate texts at different levels of granularity to learn text em...
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Article
A chemical probe to modulate human GID4 Pro/N-degron interactions
The C-terminal to LisH (CTLH) complex is a ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via its substrate receptor Glucose-Induced Degradation 4 (GID4), but its function and substrate...
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Article
Open AccessThe NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif
PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...
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Article
Local discriminative graph convolutional networks for text classification
Recently, graph convolutional networks (GCNs) has demonstrated great success in the text classification. However, the GCN only focuses on the fitness between the ground-truth labels and the predicted ones. Ind...
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Article
Open AccessThe β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance
High-intensity chemotherapy regimens are often used in adult T-cell lymphoblastic lymphoma (T-LBL) patients. Nevertheless, the response rate remains unsatisfactory due to emergence of chemoresistance. Growing ...
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Article
Open AccessA small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II
Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency of SMN leads to spinal muscular atr...
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Article
Open AccessStructural basis for Gemin5 decamer-mediated mRNA binding
Gemin5 in the Survival Motor Neuron (SMN) complex serves as the RNA-binding protein to deliver small nuclear RNAs (snRNAs) to the small nuclear ribonucleoprotein Sm complex via its N-terminal WD40 domain. Addi...
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Article
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergeni...
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Chapter
Proteins That Read DNA Methylation
Covalent modification of DNA via deposition of a methyl group at the 5′ position on cytosine residues alters the chemical groups available for interaction in the major groove of DNA. This modification, thereby...
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Article
Open AccessCharacteristics and surgical outcomes of cleft palate in kabuki syndrome: a case series of 11 patients
A significant number of patients with KS have cleft palate (CP) or submucous cleft palate (SMCP) and show delayed speech development. However, few reports have discussed the characteristics of CP in KS and the...
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Article
Reply to: Binding site for MDL-801 on SIRT6
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Article
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron
Proteome integrity depends on the ubiquitin–proteasome system to degrade unwanted or abnormal proteins. In addition to the N-degrons, C-terminal residues of proteins can also serve as degradation signals (C-de...
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Article
Open AccessHow IT preparedness helped to create a digital field hospital to care for COVID-19 patients in S. Korea
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Article
Open AccessAuthor Correction: Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessSequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
SETD2 catalyzes methylation at lysine 36 of histone H3 and it has many disease connections. We investigated the substrate sequence specificity of SETD2 and identified nine additional peptide and one protein (F...
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Article
Open AccessThe β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis
Hepatocellular carcinoma (HCC) metastasis is largely responsible for HCC-associated recurrence and mortality. We aimed to identify metastasis-related long non-coding RNAs (lncRNAs) to understand the molecular ...
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Article
Open AccessEnvironmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on temporal c...
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Article
Design and verification of a micro piezoelectric motor with energy harvesting characteristic for capsule endoscope
Wireless capsule endoscopy has the distinctive advantage of providing trustworthy results without substantial discomforts to patients. However, lack of capsule active motion control and energy supply have been...
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Article
Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli
Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in ...
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Article
Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
