6 Result(s)

Article

Correction: Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases

Yeqiu Xu, Yuanzhuang Zhang, Yinzhou Luo, Guanzhen Qiu, Jie Lu… in Cell Death Discovery (2023)

Article

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases

N6-methyladenosine (m⁶A) modification, catalyzed by methyltransferase complexes (MTCs), plays many roles in multifaceted biological activities. As the most important subunit of MTCs, the METTL3-METTL14 complex is...

Yeqiu Xu, Yuanzhuang Zhang, Yinzhou Luo, Guanzhen Qiu, Jie Lu… in Cell Death Discovery (2023)

Article

Targeting mitochondrial one-carbon enzyme MTHFD2 together with pemetrexed confers therapeutic advantages in lung adenocarcinoma

Metabolic remodeling is the fundamental molecular feature of malignant tumors. Cancer cells require sufficient energy supplies supporting their high proliferative rate. MTHFD2, a mitochondrial one-carbon metab...

Juanfen Mo, Zhenzhen Gao, Li Zheng, Miaolong Yan, Min Xue… in Cell Death Discovery (2022)

Article

Circular RNAs in osteoporosis: expression, functions and roles

Osteoporosis, which is caused by an imbalance in osteoblasts and osteoclasts, is a global age-related metabolic disease. Osteoblasts induce osteocyte and bone matrix formation, while osteoclasts play an import...

Yinzhou Luo, Guanzhen Qiu, Yize Liu, Shanshan Li, Yeqiu Xu… in Cell Death Discovery (2021)

Article

AMPK activation by ASP4132 inhibits non-small cell lung cancer cell growth

Activation of adenosine monophosphate-activated protein kinase (AMPK) is able to produce significant anti-non-small cell lung cancer (NSCLC) cell activity. ASP4132 is an orally active and highly effective AMPK...

Ying-chen **a, Jian-hua Zha, Yong-Hua Sang, Hui Yin, Guo-qiu Xu… in Cell Death & Disease (2021)