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Article
Open AccessCircular RNAs in osteoporosis: expression, functions and roles
Osteoporosis, which is caused by an imbalance in osteoblasts and osteoclasts, is a global age-related metabolic disease. Osteoblasts induce osteocyte and bone matrix formation, while osteoclasts play an import...
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Article
Open AccessTargeting mitochondrial one-carbon enzyme MTHFD2 together with pemetrexed confers therapeutic advantages in lung adenocarcinoma
Metabolic remodeling is the fundamental molecular feature of malignant tumors. Cancer cells require sufficient energy supplies supporting their high proliferative rate. MTHFD2, a mitochondrial one-carbon metab...
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Article
Open AccessNovel insights into the METTL3-METTL14 complex in musculoskeletal diseases
N6-methyladenosine (m6A) modification, catalyzed by methyltransferase complexes (MTCs), plays many roles in multifaceted biological activities. As the most important subunit of MTCs, the METTL3-METTL14 complex is...
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Article
Open AccessCorrection: Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases