-
Article
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an oncogenic gene in the progression of several malignancies. Nevertheless, the roles and me...
-
Article
Extraction of Nickel from Ultramafic Nickel Sulfide Concentrate by Metallic Iron Addition
Abundant low-grade nickel sulfide ore reserves hold potential as nickel resources but are hindered by high magnesium silicate content, limiting efficient utilization. The authors investigated the possibility o...
-
Article
Achieving 19% efficiency in non-fused ring electron acceptor solar cells via solubility control of donor and acceptor crystallization
Non-fused ring electron acceptors (NFREAs) potentially have lower synthetic costs than their fused counterparts. However, the low backbone planarity and the presence of bulky substituents adversely affect the ...
-
Article
Open AccessRelationships between oral function, dietary intake and nutritional status in older adults aged 75 years and above: a cross-sectional study
Malnutrition is related to impaired oral health and function that causes poor dietary intake, declining the general health of older adults. The role of dietary intake in the association between oral function a...
-
Article
Open AccessMethylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway
Hepatocellular carcinoma (HCC) has a high mortality rate, and the mechanisms underlying tumor development and progression remain unclear. However, inactivated tumor suppressor genes might play key roles. DNA m...
-
Article
Open AccessDesign, simulation, and testing of a tunable MEMS multi-threshold inertial switch
This paper presents a tunable multi-threshold micro-electromechanical inertial switch with adjustable threshold capability. The demonstrated device combines the advantages of accelerometers in providing quanti...
-
Article
Open AccessThe involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells
Facial nerve injury often results in poor prognosis due to the challenging process of nerve regeneration. Neuregulin-1, a human calmodulin, is under investigation in this study for its impact on the reparative...
-
Article
Open AccessTKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents as the second leading cause of cancer-related mortality. DNA damage-based radiotherapy (RT) play...
-
Article
Visual inspection via a global-to-local optimization method for agarwood sticks
Chemical composition analysis, chromatography and spectroscopy are dominate quality evaluation methods for agarwood, which are cumbersome and time-consuming. To facilitate its quality evaluation, a global-to-l...
-
Article
Contract design considering data driven marketing: with and without the cap and trade regulation
Due to the natural advantage of data acquisition, data driven marketing (DDM) has been widely adopted online. The major concern of managers, especially when facing severe environmental issues, is to adjust pro...
-
Article
Analysis of phase preservation and interferometric offset test in sparse SAR imaging
Sparse synthetic aperture radar (SAR) imaging has emerged as a reliable microwave imaging scheme in the recent decade and excels in down-sampling reconstruction and full-sampling performance improvements such ...
-
Article
Open AccessPRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6
Macrophages play significant roles in innate immune responses and are heterogeneous cells that can be polarized into M1 or M2 phenotypes. PRMT2 is one of the type I protein arginine methyltransferases involved...
-
Chapter and Conference Paper
GaussTS: Towards Time Series Data Management in OpenGauss
The rapid advancement of sensor technology presents novel challenges in the efficient management of large scale time series data. In this demo, we demonstrate a time series data management module named GaussTS...
-
Article
Open AccessThe role of m6A epigenetic modifications in tumor coding and non-coding RNA processing
Epigenetic modifications of RNA significantly contribute to the regulatory processes in tumors and have, thus, received considerable attention. The m6A modification, known as N6-methyladenosine, is the predomi...
-
Article
Open AccessEffect of the prism-interprisms three-dimension spatial microstructure on the enamel bond strength
The prism-interprisms level of the enamel hierarchical microstructure is the largest degree of structural variation and most sophisticated structural adaptation. We studied the effect of the prism-interprisms ...
-
Article
Open AccessFNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment
Ischaemia of the heart and limbs attributable to compromised blood supply is a major cause of mortality and morbidity. The mechanisms of functional angiogenesis remain poorly understood, however. Here we show ...
-
Article
Open AccessA preoperative nomogram predicting risk of lymph node metastasis for early-stage cervical cancer
This study aimed to develop a preoperative nomogram based on clinical and pathological characteristics to provide a more individualized and accurate estimation of lymph node metastasis (LNM) in patients with e...
-
Article
Open AccessKinetically matched C–N coupling toward efficient urea electrosynthesis enabled on copper single-atom alloy
Chemical C–N coupling from CO2 and NO3–, driven by renewable electricity, toward urea synthesis is an appealing alternative for Bosch–Meiser urea production. However, the unmatched kinetics in CO2 and NO3– reduct...
-
Article
METTL3 Mediated MALAT1 m6A Modification Promotes Proliferation and Metastasis in Osteosarcoma Cells
As one of the most ubiquitous types of posttranscriptional modification, N6-methyladenosine (m6A) is extensively implicated in almost all types of cancers, including osteosarcoma. Our previous research partial...
-
Article
Preparation of High Nickel Grade Ferronickel From Nickel Sulfide Concentrate with Minimal Sulfur Dioxide Emission
Nickel is a key element for stainless steel and lithium-ion batteries. However, the conventional extraction of nickel from sulfide ores generates large amounts of sulfur dioxide and slag and demands complex-re...
