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Article
GSTM2 is a key molecular determinant of resistance to SG-ARIs
Prostate cancer (PCa) continues to threaten men’s health, and treatment targeting the androgen receptor (AR) pathway is the major therapy for PCa patients. Several second-generation androgen receptor inhibitor...
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Article
Geometric error compensation of five-axis ball-end milling based on tool orientation optimization and tool path smoothing
Geometric error compensation may affect the quality of the machined surface textures due to the arbitrary adjustment of cutter locations. This paper proposes one geometric error compensation of five-axis ball-...
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Article
p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer
Blockade of programmed death-ligand 1 (PD-L1) by therapeutic antibodies has shown to be a promising strategy in cancer therapy, yet clinical response in many types of cancer, including prostate cancer (PCa), i...
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Article
Open AccessO-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth
The pentose phosphate pathway (PPP) plays a critical role in macromolecule biosynthesis and maintaining cellular redox homoeostasis in rapidly proliferating cells. Upregulation of the PPP has been shown in sev...