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Article
Alloferon Mitigates LPS-Induced Endometritis by Attenuating the NLRP3/CASP1/IL-1β/IL-18 Signaling Cascade
Endometritis is an inflammatory reaction of the uterine lining that can lead to infertility. Alloferon, a linear non-glycosylated oligopeptide, has been recognized for its potent anti-inflammatory and immunomo...
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Article
Transcriptomic Responses and Larval-Stage Growth of Protandrous Yellowfin Seabream (Acanthopagrus Latus) to Different Polyethylene Microplastics Exposure
Polyethylene microplastics (PE-MPs) were widespread in the marine environment; thus, their influences on marine hermaphroditic fish cannot be ignored. This study intends to evaluate the adverse biological effe...
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Article
Open AccessOxidative modification of miR-30c promotes cardiac fibroblast proliferation via CDKN2C mismatch
The response of cardiac fibroblast proliferation to detrimental stimuli is one of the main pathological factors causing heart remodeling. Reactive oxygen species (ROS) mediate the proliferation of cardiac fibr...
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Article
Open AccessDisruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection
The pulmonary endothelium is a dynamic and metabolically active monolayer of endothelial cells. Dysfunction of the pulmonary endothelial barrier plays a crucial role in the acute lung injury (ALI) and acute re...
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Article
Effect of Salinity on the Development and Dormancy of Cladonema digitatum
Some hydrozoan species are known for their high adaptability and dormancy ability, e.g., Cladonema species, which are also promising model organisms. Since salinity affects the development and distribution of hyd...
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Article
Open AccessSex differences and dietary patterns in the association of air pollutants and hypertension
Hypertension is one of the major public health problems in China. Limited evidence exists regarding sex differences in the association between hypertension and air pollutants, as well as the impact of dietary ...
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Article
Seascapes Shaped the Local Adaptation and Population Structure of South China Coast Yellowfin Seabream (Acanthopagrus latus)
Understanding the genetic composition and regional adaptation of marine species under environmental heterogeneity and fishing pressure is crucial for responsible management. In order to understand the genetic ...
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Article
Plasma Apo-E mediated corticospinal tract abnormalities and suicidality in patients with major depressive disorder
This study aims to explore the link between Apo-E, brain white matter, and suicide in patients with major depressive disorder (MDD) to investigate the potential neuroimmune mechanisms of Apo-E that may lead to...
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Article
Open AccessSystemic inflammatory biomarkers in Schizophrenia are changed by ECT administration and related to the treatment efficacy
Immune inflammation has long been implicated in the pathogenesis of schizophrenia. Despite as a rapid and effective physical therapy, the role of immune inflammation in electroconvulsive therapy (ECT) for schi...
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Article
Pathway from childhood trauma to nonsuicidal self-injury in adolescents with major depressive disorder: the chain-mediated role of psychological resilience and depressive severity
This study aimed to explore the pathway from childhood trauma to nonsuicidal self-injury (NSSI) in adolescents with major depressive disorder (MDD) and to examine the chain-mediating role of psychological resi...
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Article
Open AccessWarming-induced hydrothermal anomaly over the Earth’s three Poles amplifies concurrent extremes in 2022
Climate warming is causing an increase in the frequency and severity of heatwaves and extreme precipitation events, posing a threat to both socioeconomic stability and human lives. In 2022, five record-breakin...
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Article
Open AccessCircular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis
Circular RNAs are enriched in cardiac tissue and play important roles in the pathogenesis of heart diseases. In this study, we aimed to investigate the regulatory mechanism of a conserved heart-enriched circRN...
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Article
Open AccessTRPV1+ neurons alter Staphylococcus aureus skin infection outcomes by affecting macrophage polarization and neutrophil recruitment
The interaction between the nervous system and the immune system can affect the outcome of a bacterial infection. Staphylococcus aureus skin infection is a common infectious disease, and elucidating the relations...
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Article
Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats
Ischemic stroke is a worldwide disease that seriously threatens human health, and there are few effective drugs to treat it. Dihydromyricetin (DHM) has anti-inflammatory, antioxidant, and antiapoptotic functio...
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Article
Rumination mediates the relationship between childhood trauma and depressive symptoms in schizophrenia patients
Rumination and childhood trauma are related to depressive symptoms in clinical and non-clinical individuals. This is the first study aimed to test the mediating effect of rumination on the relationship between...
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Article
Open AccessAutonomous robotic surgery for zygomatic implant placement and immediately loaded implant-supported full-arch prosthesis: a preliminary research
A patient with extensive atrophy of the alveolar ridge in the posterior portion of the maxilla was selected to complete an experimental and clinical case of the robotic zygomatic implant to investigate the via...
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Article
Analysis of the Differential Expression and Antiviral Activity of Porcine Interferon-α In Vitro
Porcine interferon α (poIFN-α) is a crucial cytokine that can prevent and treat viral infections. Seventeen functional porcine IFN-α subtypes were found in the porcine genome. In this study, multiple sequence ...
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Article
Open AccessIncreased cortical structural covariance correlates with anhedonia in schizophrenia
Anhedonia is a common symptom in schizophrenia and is closely related to poor functional outcomes. Several lines of evidence reveal that the orbitofrontal cortex plays an important role in anhedonia. In the pr...
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Article
Transparent and shape-memory cellulose paper reinforced by vitrimer polymer for efficient light management and sustainability
The functional paper holds significant potential in some special fields, which has achieved great development. Nevertheless, using cellulose paper to fabricate functional paper, which integrates transparency, ...
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Article
Chromosome-level Genome Assembly of Acanthopagrus latus Provides Insights into Salinity Stress Adaptation of Sparidae
The yellowfin seabream, Acanthopagrus latus, is widely distributed throughout the Indo-West Pacific. This species, as a euryhaline Sparidae fish, inhabits in coastal environments with large and frequent salinity ...
