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Article
Open AccessPreclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still needed, particularly for individuals in whom vaccines are less effective, such as the immunocompromised, to preven...
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Article
Performance analysis of a Queueing system based on vacation with fault repairable and spare servers in the MP2P network
Peer-to-Peer (P2P) network is a logical layer distributed network built on the physical network, and nowadays the communication of mobile P2P (MP2P) network in various wireless environments is also develo** ...
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Article
Open AccessClinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8
The pathogenicity and virulence of the Omicron strain have weakened significantly pathogenesis of Omicron variants. Accumulating data indicated accessory proteins play crucial roles in host immune evasion and ...
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Article
Open AccessPrevalence and predisposing factors of depressive symptoms in continuous ambulatory peritoneal dialysis patients: a cross-sectional single center study
The aim of this study was to identify the prevalence of the depressive symptoms and the factors associated with the depressive symptoms in peritoneal dialysis patients.
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Article
Open AccessCorrection: Heparanase promotes endothelial-to-mesenchymal transition in diabetic glomerular endothelial cells through mediating ERK signaling
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Article
Open AccessHeparanase promotes endothelial-to-mesenchymal transition in diabetic glomerular endothelial cells through mediating ERK signaling
Glomerular endothelial cells (GEnCs) dysfunction occurs at the early stage of diabetic nephropathy (DN). One of its characteristics is endothelial-to-mesenchymal transition (EndMT). Heparanase (HPSE) is the on...
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Article
Study on coupling between mineral resources exploitation and the mining ecological environment in Shanxi Province
Due to rapid socioeconomic development, seeking the coordination of resources exploitation and the ecological environment has become an objective requirement for the healthy and sustainable development of the ...
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Article
Open AccessTransient neonatal antibiotic exposure increases susceptibility to late-onset sepsis driven by microbiota-dependent suppression of type 3 innate lymphoid cells
Extended early antibiotic exposure in the neonatal intensive care unit is associated with an increased risk for the development of late-onset sepsis (LOS). However, few studies have examined the mechanisms inv...
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Article
Open AccessDecreased Ang-(1–7) and Downregulated Intrarenal RAS May Contribute to the Direct Podocyte Injury With Proteinuria in Preeclampsia
The mechanisms of proteinuria development in preeclampsia (PE) are still enigmatic. Renin-angiotensin system (RAS) components may play a role. Maternal serum and urinary concentrations of angiotensin-(1-7) [An...
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Article
EGFR Mimotope Reduces the Expression of LYVE-1 in the Intestine from the M3R Immunized Mice
Primary Sjögren’s syndrome (pSS) is a prototypic autoimmune disease characterized by immune injury to the salivary and lacrimal glands with other systemic manifestations. Recent studies showed the adaptive aut...
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Chapter
Design of a Chaotic Pulse-Position Modulation Circuit
An analog chaotic modulation circuit based on Chua’s circuit is proposed to generate a chaotic pulse-position signal. The circuit is designed with standard electronic components, and the parameters of the gene...
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Article
Performance of the creatinine and cystatin C-based equations for estimation of GFR in Chinese patients with chronic kidney disease
Currently, creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation has been recommended to assess GFR in CKD patients. However, it is still obscure whether those equations performe...
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Article
Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells
In diabetic kidney disease (DKD), epithelial-to-mesenchymal transition (EMT) is a classic pathological process in tubular damage. Oxidative stress is considered to play an important role in DKD. Astragaloside ...
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Chapter and Conference Paper
Reducing EMI in a PC Power Supply with Chaos Control
A chaos control methodology has been proposed for suppressing EMI in DC–DC converters in the former research. In this paper, this method is applied in the power supply ATX as a real practical application, wher...
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Article
Effects of Angiogenic Factors, Antagonists, and Podocyte Injury on Development of Proteinuria in Preeclampsia
Proteinuria is universal to all patients with preeclampsia. We examined the urinary podocytes in women with preeclampsia (n = 14), gestational hypertension (n = 14), and normal pregnancy. Maternal serum and ur...
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Article
Open AccessHeparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway
Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparan...
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Article
A Comprehensive Therotical Investigation of Intramolecular Proton Transfer in the Excited States for Some Newly-designed Diphenylethylene Derivatives Bearing 2-(2-Hydroxy-Phenyl)-Benzotriazole Part
This article presents a comprehensive therotical investigation of excited state intramolecular proton transfer (ESIPT) for some newly-designed diphenylethylene derivatives containing 2-(2-hydroxy-phenyl)-benzo...
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Article
Synthesis and Spectroscopy of Novel Branched Fluorescent Dyes Containing Benzophenone Parts and the Possibility as Fluorescence Probes
This paper describes a new fluorescent family of branched dyes containing benzophenone unit including 4-N, N-diphenylamino-4′-phenacyl-stilbene (C1), 4,4′-di(4-benzoylphenylethylene)yl-triphenylamine (C2) and 4,4...
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Article
In situ preparation of self-bonded zeolite MCM-22 bodies by vapor-phase transport method
Self-bonded bodies of zeolite MCM-22 were prepared by vapor-phase transport method. The resultant materials were characterized by means of X-ray diffraction, scanning electron microscope, mercury porosimetry, ...
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Article
Membrane permeability of fructose-1,6-diphosphate in lipid vesicles and endothelial cells
Fructose-1,6-diphosphate (FDP) is a glycolytic intermediate which has been used an intervention in various ischemic conditions for two decades. Yet whether FDP can enter the cell is under constant debate. In t...
