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Article
A fine-grained convolutional recurrent model for obstructive sleep apnea detection
Obstructive Sleep Apnea (OSA) is a prevalent sleep-related breathing disorder that leads to various health issues such as hypertension, heart disease, diabetes, and stroke. In order to achieve a convenient, ro...
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Article
Inverse Design and Application Periodic Barriers for Isolating Ambient Vibration Based on Deep Learning
The vibrations and noises caused by traffic, machine operation, and construction activity have become a serios concern. Fortunately, the use of elastic metamaterials proposes new methods for reducing those vib...
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Article
A study on the monitoring of landslide deformation disasters in Wenxian County, Longnan City based on different time-series InSAR techniques
Interferometry Synthetic Aperture Radar (InSAR) technology is widely employed in the identification of geological hazards. However, in regions characterized by high mountains, canyons, and dense vegetation, de...
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Article
Efgartigimod in the treatment of Guillain–Barré syndrome
Guillain–Barré Syndrome (GBS) is caused by immunoglobulin G (IgG) autoantibodies. Efgartigimod, a human IgG antibody Fc fragment that acts as a natural ligand for the FcRn, can increase IgG degradation, which ...
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Article
Open AccessConstructing and Validating a Nomogram Model for Short-Term Prognosis of Patients with AChR-Ab+ GMG
This study aimed to establish and validate a nomogram prognostic model for predicting short-term efficacy of acetylcholine receptor antibody-positive (AChR-Ab+) generalized myasthenia gravis (GMG).
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Article
Open AccessRelative frequencies and clinical features of Guillain-Barré Syndrome before and during the COVID-19 pandemic in North China
Most studies investigated the relationship between COVID-19 and Guillain-Barré syndrome (GBS) by comparing the incidence of GBS before and during the pandemic of COVID-19. However, the findings were inconsiste...
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Article
Open AccessCharacterization and functional evidence for Orf2 of Streptomyces sp. 139 as a novel dipeptidase E
Aspartyl dipeptidase (dipeptidase E) can hydrolyze Asp-X dipeptides (where X is any amino acid), and the enzyme plays a key role in the degradation of peptides as nutrient sources. Dipeptidase E remains unchar...
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Article
Open AccessHarnessing sub-comb dynamics in a graphene-sensitized microresonator for gas detection
Since their inception, frequency combs generated in microresonators, known as microcombs, have sparked significant scientific interests. Among the various applications leveraging microcombs, soliton microcombs...
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Article
Climate warming worsens thermal resource utilization for practical rice cultivation in China
Rice production is sensitive to climate change and significantly affected by warming in recent years. To what extent climate warming shifted rice phenology and varied thermal resource condition were explored a...
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Article
Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019
This cohort study was performed to explore the influence of intensive care unit (ICU) quality on in-hospital mortality of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO)-supported patients in Chin...
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Article
Open AccessIn silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD
Brucella, a gram-negative intracellular bacterium, causing Brucellosis, a zoonotic disease with a range of clinical manifestations, from asymptomatic to fever, fatigue, loss of appetite, joint and muscle pain, an...
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Article
Open AccessClinical features and genetic spectrum of a multicenter Chinese cohort with myotonic dystrophy type 1
As the most common subtype of adult muscular dystrophy worldwide, large cohort reports on myotonic dystrophy type I (DM1) in China are still lacking. This study aims to analyze the genetic and clinical charact...
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Article
Open AccessThe male-to-female ratio in late-onset multiple acyl-CoA dehydrogenase deficiency: a systematic review and meta-analysis
Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is the most common lipid storage myopathy. There are sex differences in fat metabolism and it is not known whether late-onset MADD affects men and w...
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Article
Crosswind impacts on comfort of straddle monorail vehicle running on flexible track beam
Crosswind is the primary external excitation source of the straddle monorail system. To ensure the ride quality of the monorail system under crosswind, based on multi-rigid body dynamics and finite element met...
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Article
Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis. Senile plaques composed of the amyloid-β (Aβ) peptide in the brain are the core hallmarks of AD and a promising...
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Article
Diverse thermal responses of the growth, photosynthesis, lipid and fatty acids in the terrestrial oil-producing microalga Vischeria sp. WL1
Temperature is a common and effective environmental driver employed for promoting lipid accumulation in microalgae, while the thermal reaction norms associated with total lipid, fatty acid, photosynthesis and ...
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Article
Open AccessTherapeutic effectiveness of anlotinib combined with etoposide in extensive-stage small-cell lung cancer: a single-arm, phase II trial
Anlotinib plus chemotherapy as first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC) achieves good efficacy, but there is still room for improvement. This clinical study examined the effect...
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Article
Identification of Molecular Markers Predicting the Outcome of Anti-thrombotic Therapy After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome and Atrial fibrillation: Evidence from a Meta-analysis and Experimental Study
Acute coronary syndrome (ACS) and atrial fibrillation (AF) often coexist in clinical practice, and patients with these conditions often have a critical illness with high risk of both ischemia and bleeding. Thi...
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Article
Diagnostic utility of different dysphagia screening tools to detect dysphagia in individuals with amyotrophic lateral sclerosis
Dysphagia is a common and serious clinical symptom of amyotrophic lateral sclerosis (ALS). The study aimed to evaluate the diagnostic utility of four dysphagia screening tools in ALS, including the ALS Functio...
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Article
Open AccessCarbapenem is not always the best choice in the treatment of septic shock
Septic shock is a global public health burden. In addition to the improvement of the level of individual care, the improvement of the overall hospital quality control management is also an essential key aspect...
