10 Result(s)
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Article
Open AccessIn vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy
Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4 (GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However, the wide application of GPX4...
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Article
Open AccessExperimental study on the mechanism of ice layer formation in fractured rock masses in cold regions
The formation and growth of ice layers in fractured rock masses is one of the main causes of frost weathering in bedrock in cold regions. The mechanism of ice layer formation in fractured rock masses was simul...
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Article
Open AccessPro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs
Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantita...
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Open AccessExperimental study on granite acoustic emission and micro-fracture behavior with combined compression and shear loading: phenomenon and mechanism
One element that is essential to consider in underground mining engineering applications is the possibility of pillar failure, which can result in deadly geological disasters, including earthquakes and surface...
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Open AccessThe MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
The antiandrogen enzalutamide (Enz) has improved survival in castration resistant prostate cancer (CRPC) patients. However, most patients eventually develop Enz resistance that may involve inducing the androge...
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Article
Open AccessA tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes an...
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Open AccessLncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling
While the antiandrogen enzalutamide (Enz) extends the castration resistant prostate cancer (CRPC) patients’ survival an extra 4.8 months, it might also result in some adverse effects via inducing the neuroendo...
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Open AccessUse of artificial neural networks to identify the predictive factors of extracorporeal shock wave therapy treating patients with chronic plantar fasciitis
The purpose of our study is to identify the predictive factors for a minimum clinically successful therapy after extracorporeal shock wave therapy for chronic plantar fasciitis. The demographic and clinical ch...
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Article
Open AccessDielectric properties of Y and Nb co-doped TiO2 ceramics
In this work, the (Y0.5Nb0.5)xTi1−xO2 (x = 0.001, 0.01, 0.02, 0.04, 0.06 and 0.1) ceramics (as called YNTO) were fabricated by synthesized through a standard solid-state reaction. As revealed by the X-ray diffrac...
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Article
Open AccessPreclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform
Therapeutic outcomes of combination chemotherapy have not significantly advanced during the past decades. This has been attributed to the formidable challenges of optimizing drug combinations. Testing a matrix...
