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  1. No Access

    Article

    Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase

    To evaluate the function of cysteine residues of the Src kinase, we constructed a series of Src mutants in which some of cyteines were replaced to alanines. With these mutants, we studied the effect of SH-alky...

    Myat Lin Oo, Takeshi Senga, Aye Aye Thant, ARM Ruhul Amin, Pengyu Huang in Oncogene (2003)

  2. No Access

    Article

    Experimental study of the effect of the Bax gene on human hepatocellular carcinoma and therapy via hepatic artery delivery

    To investigate apoptosis induced by Bax in hepatocellular carcinoma cells and to examine the results of 2 different routes for in vivo gene delivery.

    Zhi Guo, Wenge **ng, Haishan Yang, Lin Wang in Chinese Journal of Clinical Oncology (2005)

  3. No Access

    Article

    In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin

    Epidermal growth factor receptor (EGFR) plays an important role in the growth and metastasis of many solid tumors. Strategies that target EGFR hold promising therapeutic potential for the treatment for non-sma...

    **kun Zhou, Ji Qiu, Zhen Wang, Nongyu Huang in Journal of Cancer Research and Clinical On… (2012)

  4. No Access

    Article

    MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer

    Studies have shown that microRNA-148a (miR-148a) was proved to be silenced while DNA methyltransferase 1 (DNMT1) was over-expressed in gastric cancer. But the mechanism of aberrant expression of miR-148a and D...

    Akao Zhu, Jiazeng **a, Junbo Zuo, Shimao **, Hong Zhou, Lubin Yao in Medical Oncology (2012)

  5. No Access

    Article

    Laparoscopic Partial Nephrectomy for T1 Renal Cell Carcinoma: Comparison of Two Resection Techniques in a Multi-institutional Propensity Score-Matching Analysis

    Enucleoresection is defined as presence of a minimal paratumor parenchyma that allows for clear visualization of the tumor’s contours during partial nephrectomy (PN). Because there is variability in published ...

    Wen Dong MD, Tianxin Lin MD, Fei Li PhD, Yong Fang PhD in Annals of Surgical Oncology (2016)

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    Article

    Differences Between the Intestinal Lumen Microbiota of Aberrant Crypt Foci (ACF)-Bearing and Non-bearing Rats

    Multiple factors including host–microbiota interaction could contribute to the conversion of healthy mucosa to sporadic precancerous lesions. An imbalance of the gut microbiota may be a cause or consequence of...

    **uli **ao, Wenbo Long, Tingyu Huang, Tian **a, Rupei Ye in Digestive Diseases and Sciences (2018)

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    Article

    ASO Author Reflections: Radiomics-Based Strategy of Combining Conventional Clinico-Radiological Characteristics with Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma

    Jun Li MD, Shengyu Huang MD, Shuaitong Zhang PhD in Annals of Surgical Oncology (2022)

  8. No Access

    Article

    ASO Visual Abstract: Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography

    Shuaitong Zhang PhD, Shengyu Huang MD, Wei He MD in Annals of Surgical Oncology (2022)

  9. No Access

    Article

    Radiomics-Based Preoperative Prediction of Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma Using Contrast-Enhanced Computed Tomography

    Lymph node (LN) metastasis is significantly associated with worse prognosis for patients with intrahepatic cholangiocarcinoma (ICC). Improvement in preoperative assessment on LN metastasis helps in treatment d...

    Shuaitong Zhang PhD, Shengyu Huang MD, Wei He MD in Annals of Surgical Oncology (2022)

  10. Article

    Open Access

    Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer

    Radiochemotherapy (RCT) is a powerful treatment for cervical cancer, which affects not only malignant cells but also the immune and stromal compartments of the tumor. Understanding the remodeling of the local ...

    Chao Liu, **aohui Li, Qingyu Huang, Min Zhang in Signal Transduction and Targeted Therapy (2023)

  11. Article

    Open Access

    Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism

    The intestinal microbiota has been associated with host immunity as well as psoriasis; however, the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically. Here, we sou...

    Qixiang Zhao, Jiadong Yu, Hong Zhou in Signal Transduction and Targeted Therapy (2023)

  12. Article

    Open Access

    Deciphering tumor-infiltrating dendritic cells in the single-cell era

    Dendritic cells (DCs) serve as a pivotal link connecting innate and adaptive immunity by processing tumor-derived antigens and activating T cells. The advent of single-cell sequencing has revolutionized the ca...

    Qingyu Huang, Fuhao Wang, Di Hao, **nyu Li in Experimental Hematology & Oncology (2023)

  13. Article

    Open Access

    Low platelet count at diagnosis of anti-neutrophil cytoplasmic antibody-associated vasculitis is correlated with the severity of disease and renal prognosis

    Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease that involves inflammation of blood vessels. There is increasing evidence that platelets play a crucial role not only in...

    Yanli **, Fangyuan Wang, Jiale Tang, Liying Luo in Clinical and Experimental Medicine (2024)