4 Result(s)
within
English
Medicine & Public Health
Cell Biology
**ngyu Huang
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Article
Cysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase
To evaluate the function of cysteine residues of the Src kinase, we constructed a series of Src mutants in which some of cyteines were replaced to alanines. With these mutants, we studied the effect of SH-alky...
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Article
Allogeneic hematopoietic stem cell transplantation overcome the poor prognosis of patients with IKZF1plus CD20–a very high-risk subtype in B-cell acute lymphoblastic leukemia
Genetic deletions of IKZF1 (IKZF1del) and IKZF1del plus other mutations (IKZF1plus) have been identified in B-cell acute lymphoblastic leukemia (B-ALL) with a poor prognosis. Herein, we investigated the combinati...
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Article
Open AccessSingle-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer
Radiochemotherapy (RCT) is a powerful treatment for cervical cancer, which affects not only malignant cells but also the immune and stromal compartments of the tumor. Understanding the remodeling of the local ...
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Article
Open AccessIntestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism
The intestinal microbiota has been associated with host immunity as well as psoriasis; however, the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically. Here, we sou...
