22 Result(s)
-
Article
Open AccessWFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like skin lesions, dry skin, severe itching, and recurrent recurrence. The whey acidic protein four-disulfide core domain g...
-
Article
LilrB3 is a putative cell surface receptor of APOE4
The three isoforms of apolipoprotein E (APOE2, APOE3, and APOE4) only differ in two amino acid positions but exert quite different immunomodulatory effects. The underlying mechanism of such APOE isoform depend...
-
Article
Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge
The gut microbiota is involved in host responses to high altitude. However, the dynamics of intestinal microecology and their association with altitude-related illness are poorly understood. Here, we used a ra...
-
Article
Open AccessSerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction
Defective execution of proteases and protease inhibitors that mediate abnormal signaling cascades is emerging as a key contributor to skin diseases, such as psoriasis. SerpinB7 is identified as a skin-specific...
-
Article
Open AccessInhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis
Acute liver failure (ALF) is a severe clinical syndrome characterized by massive death of hepatocytes in a short time, resulting in coagulopathy and hepatic encephalopathy, with a high mortality in patients wi...
-
Article
Open AccessGenome-wide association analysis reveals a novel QTL CsPC1 for pericarp color in cucumber
Cucumber is an important melon crop in the world, with different pericarp colors. However, the candidate genes and the underlying genetic mechanism for such an important trait in cucumber are unknown. In this ...
-
Article
Open AccessCryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex
Nuclear pore complex (NPC) mediates nucleocytoplasmic shuttling. Here we present single-particle cryo-electron microscopy structure of the inner ring (IR) subunit from the Xenopus laevis NPC at an average resolut...
-
Article
Open AccessCryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex
Nuclear pore complex (NPC) shuttles cargo across the nuclear envelope. Here we present single-particle cryo-EM structure of the nuclear ring (NR) subunit from Xenopus laevis NPC at an average resolution of 5.6 Å....
-
Article
The landscape of promoter-centred RNA–DNA interactions in rice
Chromatin-associated RNAs play key roles in various biological processes. However, both their repository and conjugation genomic loci and potential functions remain largely unclear. Here, we develop an effecti...
-
Article
Open AccessCPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini
High-throughput sequencing reveals the complex landscape of small noncoding RNAs (sRNAs). However, it is limited by requiring 5′-monophosphate and 3′-hydroxyl in RNAs for adapter ligation and hindered by methy...
-
Article
Open AccessGenome-wide analysis of AP2/ERF superfamily in lotus (Nelumbo nucifera) and the association between NnADAP and rhizome morphology
The AP2/ERF family is widely present in plants and plays a crucial regulatory role in plant growth and development. As an essential aquatic horticultural model plant, lotus has an increasingly prominent econom...
-
Article
Open AccessEmerging role of the Hippo pathway in autophagy
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromol...
-
Article
Open AccessStructure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis
The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron m...
-
Article
Open AccessMolecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex
The nuclear pore complex (NPC) mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells. Here we report the cryo-electron tomography (cryo-ET) structure of the luminal ring (LR) of...
-
Article
Open AccessApplication of LpxC enzyme inhibitor to inhibit some fast-growing bacteria in human gut bacterial culturomics
Culturomics can ascertain traces of microorganisms to be cultivated using different strategies and identified by matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry or 16S rDNA sequenc...
-
Article
Unraveling the feeding dynamics of Chinese mitten crab-based ecosystems using carbon and nitrogen stable isotope techniques
The Chinese mitten crab (CMC) is an economically important species that consumers prefer mainly because of its delightful taste and aroma. The taste of CMC varies depending on its environmental conditions. Con...
-
Article
TesG is a type I secretion effector of Pseudomonas aeruginosa that suppresses the host immune response during chronic infection
Pseudomonas aeruginosa is a versatile Gram-negative pathogen with intricate intracellular regulatory networks that enable it to adapt to and flourish in a variety of biotic and abiotic habitats. However, the mech...
-
Article
Open AccessInsights into the impact of flhF inactivation on Campylobacter jejuni colonization of chick and mice gut
Campylobacter jejuni (C. jejuni) is a leading cause of foodborne gastroenteritis worldwide. This bacterium lacks many of the classical virulence factors, and flagellum-associated persistent colonization has been ...
-
Article
Detection of corn oil in adulterated olive and soybean oil by carbon stable isotope analysis
The production of olive oil and soybean oil is expensive and time-consuming, and the products have high commercial value. These make the products highly susceptible to economically motivated adulteration, espe...
-
Article
Open AccessHomology-mediated end joining-based targeted integration using CRISPR/Cas9
Targeted integration of transgenes can be achieved by strategies based on homologous recombination (HR), microhomology-mediated end joining (MMEJ) or non-homologous end joining (NHEJ). The more generally used ...
