21 Result(s)
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Open AccessThe activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage grou...
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Open AccessMap** of Alzheimer’s disease related data elements and the NIH Common Data Elements
Alzheimer’s Disease (AD) is a devastating disease that destroys memory and other cognitive functions. There has been an increasing research effort to prevent and treat AD. In the US, two major data sharing res...
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Open AccessIdentification of gene variation feature for targeted therapy of non-small cell lung cancer through combined method of DNA and RNA sequencing
Next generation sequencing (NGS) is typically used to reveal tumor gene variation feature for targeted therapy of various types of human cancers, including non-small cell lung cancer (NSCLC). Here, we report t...
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Bilateral Hunter’s bow syndrome: a rare case diagnosed by dynamic digital subtraction angiography
A 27-year-old female patient suffered from recurrent episodes of dizziness, visual rotation, and intermittent right-hand numbness over one month. Symptoms persisted and were triggered by rotating the head to t...
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A web-based prediction model for long-term cancer-specific survival of middle-aged patients with early-stage gastric cancer: a multi-institutional retrospective study
This study constructed and validated a prognostic model to evaluate long-term cancer-specific survival (CSS) in middle-aged patients with early gastric cancer (EGC).
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Prognostic Analysis of Prophylactic Hyperthermic Intraperitoneal Chemotherapy for Advanced Gastric Cancer: a Propensity Score-Matched Analysis
To investigate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gastric cancer (AGC).
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Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update
The increasing number of coronavirus disease 2019 (COVID-19) infections have highlighted the long-term consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection called long COVID. ...
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Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening
Colorectal cancer (CRC) is a disease of global concern, and its increasing incidence suggests the need for early and accurate diagnosis. The aim of this study was to investigate the value of combined detection...
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The phenotype and prediction of long-term physical, mental and cognitive COVID-19 sequelae 20 months after recovery, a community-based cohort study in China
Long-term sequelae clustering phenotypes are important for precise health care management in COVID-19 survivors. We reported findings for 1000 survivors 20 months after diagnosis of COVID-19 in a community-bas...
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The role of HPV status in patients with overlap** grey zone cancer in oral cavity and oropharynx
We aimed to explore the clinicodemographic characteristics and prognosis of grey zone squamous cell cancer (GZSCC) located in the overlap** or ambiguous area of oral cavity and oropharynx and to identify val...
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Early Prediction of Malignant Edema After Successful Recanalization in Patients with Acute Ischemic Stroke
Postinterventional cerebral hyperdensities are common on non-contrast-enhanced computed tomography (CT) after endovascular thrombectomy in patients with acute ischemic stroke, which may reflect blood–brain bar...
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Correction to: Early Prediction of Malignant Edema After Successful Recanalization in Patients with Acute Ischemic Stroke
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Article
Open AccessIdentification of missing concepts in biomedical terminologies using sequence-based formal concept analysis
As biomedical knowledge is rapidly evolving, concept enrichment of biomedical terminologies is an active research area involving automatic identification of missing or new concepts. Previously, we prototyped a...
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Cerebral hyperperfusion syndrome following mechanical thrombectomy due to cardiogenic embolism
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Open AccessTargeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance
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Pulsatile tinnitus was the only manifestation of internal carotid artery dissection
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Open AccessDetecting missing IS-A relations in the NCI Thesaurus using an enhanced hybrid approach
The National Cancer Institute (NCI) Thesaurus provides reference terminology for NCI and other systems. Previously, we proposed a hybrid prototype utilizing lexical features and role definitions of concepts in...
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Open AccessThe rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies
Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an increasing public health threat in the United States and elsewhere. Fentanyl was initially approved and used for the treat...
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Article
Heat shock protein 70 is induced by pepsin via MAPK signaling in human nasal epithelial cells
Recent studies have shown that laryngopharyngeal reflux is associated with chronic rhinosinusitis. Pepsin may be a key factor involved in the injury of nasal mucosal epithelial cells, but the pathogenesis rema...
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Article
Serum anticardiolipin antibodies in patients with neuromyelitis optica spectrum disorder
The presence of anticardiolipin antibodies (ACLA) in multiple sclerosis (MS) patients has been reported, but there are some debates on the relationship between ACLA and MS. We assessed the clinical features of...
