69 Result(s)

Article

Comparative optimization of polysaccharide-based nanoformulations for cardiac RNAi therapy

Ionotropic gelation is widely used to fabricate targeting nanoparticles (NPs) with polysaccharides, leveraging their recognition by specific lectins. Despite the fabrication scheme simply involves self-assembl...

Han Gao, Sen Li, Zhengyi Lan, Da Pan, Gonna Somu Naidu, Dan Peer… in Nature Communications (2024)

Article

A solvent-free processed low-temperature tolerant adhesive

Ultra-low temperature resistant adhesive is highly desired yet scarce for material adhesion for the potential usage in Arctic/Antarctic or outer space exploration. Here we develop a solvent-free processed low-...

**aoming **e, Yulian Jiang, **aoman Yao, Jiaqi Zhang, Zilin Zhang… in Nature Communications (2024)

Article

Dual-mode harvest solar energy for photothermal Cu_2-xSe biomineralization and seawater desalination by biotic-abiotic hybrid

Biotic-abiotic hybrid photocatalytic system is an innovative strategy to capture solar energy. Diversifying solar energy conversion products and balancing photoelectron generation and transduction are critical...

Sheng-Lan Gong, YangChao Tian, Guo-** Sheng, Li-Jiao Tian in Nature Communications (2024)

Article

Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation

Calcific aortic valve disease is a prevalent cardiovascular disease with no available drugs capable of effectively preventing its progression. Hence, an efficient drug delivery system could serve as a valuable...

**yong Chen, Tanchen Ren, Lan **e, Haochang Hu, Xu Li… in Nature Communications (2024)

Article

Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death

Mutant KRAS (KRAS^MUT) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from KRAS^MUT ...

Chi Zhou, Wenxin Li, Zhenxing Liang, **anrui Wu, Si**g Cheng… in Nature Communications (2024)

Article

Risk factors of incomplete healing following medial meniscus posterior root tear repair with gracilis tendon

To evaluate the clinical efficacy and meniscus healing rates of the arthroscopically assisted tendon graft fixation of the medial meniscus posterior root tears (MMPRTs), and to identify some independent risk f...

**ngen Liao, Hongbo Li, Si Nie, Min Lan in Scientific Reports (2023)

Article

Measurement of the \( ^{181} \) Ta( \(n,\gamma \) ) cross sections up to stellar s-process temperatures at the CSNS Back-n

The neutron capture cross section of \( ^{181} \) 181 ...

Zhendong An, Weiwei Qiu, Wei Jiang, Gaole Yang, … in Scientific Reports (2023)

Article

Deep learning and ultrasound feature fusion model predicts the malignancy of complex cystic and solid breast nodules with color Doppler images

This study aimed to evaluate the performance of traditional-deep learning combination model based on Doppler ultrasound for diagnosing malignant complex cystic and solid breast nodules. A conventional statisti...

Han Liu, Chun-Jie Hou, **g-Lan Tang, Li-Tao Sun, Ke-Feng Lu… in Scientific Reports (2023)

Article

Circadian regulation of developmental synaptogenesis via the hypocretinergic system

The circadian clock orchestrates a wide variety of physiological and behavioral processes, enabling animals to adapt to daily environmental changes, particularly the day-night cycle. However, the circadian clo...

Xu-Fei Du, Fu-Ning Li, **ao-Lan Peng, Bing Xu, Yu Zhang, Guang Li… in Nature Communications (2023)

Article

A propensity score matching study on survival benefits of radiotherapy in patients with inoperable hepatocellular carcinoma

With the advancements in radiotherapy (RT) in recent years, several studies have shown that RT can significantly prolong the survival of patients with hepatocellular carcinoma (HCC). As a noninvasive treatment...

Hao Zeng, Ke Su, **ao**g Chen, Xueting Li, Lianbin Wen… in Scientific Reports (2023)

Article

Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogene...

Yanming Ren, Zongyao Huang, Lingling Zhou, Peng **ao, Junwei Song… in Nature Communications (2023)

Article

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis

T helper 17 (Th17) cells are a subset of CD4⁺ T helper cells involved in the inflammatory response in autoimmunity. Th17 cells secrete Th17 specific cytokines, such as IL-17A and IL17-F, which are governed by the...

Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou… in Nature Communications (2023)

Article

Surface-redox sodium-ion storage in anatase titanium oxide

Sodium-ion storage technologies are promising candidates for large-scale grid systems due to the abundance and low cost of sodium. However, compared to well-understood lithium-ion storage mechanisms, sodium-io...

Qiulong Wei, **aoqing Chang, Danielle Butts, Ryan DeBlock, Kun Lan… in Nature Communications (2023)

Article

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor^1–4. However, the receptor for NeoCoV—the closest known MERS-CoV relativ...

Qing **ong, Lei Cao, Chengbao Ma, M. Alejandra Tortorici, Chen Liu, Junyu Si… in Nature (2022)

Article

Planar chiral metasurfaces with maximal and tunable chiroptical response driven by bound states in the continuum

Optical metasurfaces with high quality factors (Q-factors) of chiral resonances can boost substantially light-matter interaction for various applications of chiral response in ultrathin, active, and nonlinear ...

Tan Shi, Zi-Lan Deng, Guangzhou Geng, **anzhi Zeng, Yixuan Zeng… in Nature Communications (2022)

Article

The impact of driver mutation on the treatment outcome of early-stage lung cancer patients receiving neoadjuvant immunotherapy and chemotherapy

Neoadjuvant immunotherapy and chemotherapy have improved the major pathological response (MPR) in patients with early-stage operable non-small cell lung cancer (NSCLC). This study aimed to assess whether the p...

Po-Lan Su, Jung-Yueh Chen, Chang-Yao Chu, Yi-Lin Chen, Wan-Li Chen… in Scientific Reports (2022)

Article

Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of cell death that is triggered by iron-dependent lipid peroxidation and contributes to the pathogenesis of several inflam...

Shan-Shan **e, Yan Deng, Sheng-lan Guo, Jia-quan Li, Ying-chuan Zhou… in Scientific Reports (2022)

Article

Author Correction: Compatibility study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function

**-Lan Lin, Zhi-Cheng Li, Rui-Fang **e, You-Hua Wang, **n Zhou in Scientific Reports (2022)

Article

Observation of localized magnetic plasmon skyrmions

Optical skyrmions have recently been constructed by tailoring vectorial near-field distributions through the interference of multiple surface plasmon polaritons, offering promising features for advanced inform...

Zi-Lan Deng, Tan Shi, Alex Krasnok, ** Li, Andrea Alù in Nature Communications (2022)

Article

Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers

Colorectal cancer is one of the most common cancers in the world. Although genomic mutations and single nucleotide polymorphisms have been extensively studied, the epigenomic status in colorectal cancer patien...

Qing-Lan Li, **ang Lin, Ya-Li Yu, Lin Chen, Qi-**n Hu, Meng Chen… in Nature Communications (2021)