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Open AccessRadiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...
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Article
Open AccessEmergent normal fluid in the superconducting ground state of overdoped cuprates
The microscopic mechanism for the disappearance of superconductivity in overdoped cuprates is still under heated debate. Here we use scanning tunneling spectroscopy to investigate the evolution of quasiparticl...
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Article
Highly Compressible and Lightweight Al2O3/PCNF@ANF Aerogels for Effective Oil Adsorption and Separation
Due to the lightweight feature, superior hydrophobic and oleophilic property, as well as remarkable adsorption capability, carbon-based aerogels have become appealing adsorbents for removing leaking oils and t...
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Article
Open AccessFactors associated with SARS-CoV-2 vaccine hesitancy after stroke: a cross-sectional study
The vaccination status of post-stroke patients, who are at high risk of severe outcomes from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a significant concern, yet it remains unclear. We a...
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GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma
Chimeric antigen receptor-expressing T (CAR-T) cells induce robust antitumor responses in patients with hematologic malignancies. However, CAR-T cells exhibit only limited efficacy against solid tumors such as...
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E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1
The circadian clock is the inner rhythm of life activities and is controlled by a self-sustained and endogenous molecular clock, which maintains a ~ 24 h internal oscillation. As the core element of the circad...
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Article
Genome constitution and evolution of Elymus atratus (Poaceae: Triticeae) inferred from cytogenetic and phylogenetic analysis
Elymus atratus (Nevski) Hand.-Mazz. is perennial hexaploid wheatgrass. It was assigned to the genus Elymus L. sensu stricto based on morphological characters. Its genome constitution has not been disentangled yet...
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Article
Optimized online filter stack spectrometer for ultrashort X-ray pulses
Currently, with the advent of high-repetition-rate laser-plasma experiments, the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very impor...
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Article
Compounds from the Leaves and Stems of Erythrina crista-galli
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Open AccessImmune persistence after different polio sequential immunization schedules in Chinese infants
Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented s...
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Article
Open AccessDeep learning algorithm-based multimodal MRI radiomics and pathomics data improve prediction of bone metastases in primary prostate cancer
Bone metastasis is a significant contributor to morbidity and mortality in advanced prostate cancer, and early diagnosis is challenging due to its insidious onset. The use of machine learning to obtain prognos...
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Article
Open AccessComprehensive analysis of metabolites in the mycelium of Cordyceps fumosorosea cultured on Periplaneta americana
Cordyceps fumosorosea is one of the common species within the Cordyceps genus, which are cultured on Periplaneta americana. This study aimed to determine the composition of bioactive compounds, including β-glucan...
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Open AccessTrajectories of anxiety and depression among Chinese men who have sex with men on pre-exposure prophylaxis: a group-based trajectory model approach
Anxiety and depression can influence adherence to Pre-exposure Prophylaxis (PrEP). However, there is limited research on the temporal dynamics of anxiety and depression among men who have sex with men (MSM) us...
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Insight into vertical piezoelectric characteristics regulated thermal transport in van der Waals two-dimensional materials
The urgent demand of extreme (ultra-high/low) thermal conductivity materials is triggered by the high-power device, where exploring the theories and mechanisms of regulating thermal transport properties plays ...
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Article
Morphological and phylogenetic analyses reveal a new species of Anthracophyllum (Omphalotaceae, Agaricales) in Zhejiang Province, China
During the investigations of macrofungi resources in Zhejiang Province, China, an interesting wood rot fungus was collected. Based on morphological and molecular phylogenetic studies, it is described as a new ...
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Article
Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache: A Secondary Analysis of A Randomized Controlled Trial
To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache (CTTH).
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Article
Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells
The mechanism of ketamine-induced neurotoxicity development remains elusive. Mitochondrial fusion/fission dynamics play a critical role in regulating neurogenesis. Therefore, this study was aimed to evaluate w...
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Article
Open Access50 Years of quantum chromodynamics
Quantum Chromodynamics, the theory of quarks and gluons, whose interactions can be described by a local SU(3) gauge symmetry with charges called “color quantum numbers”, is reviewed; the goal of this review is...
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Article
Open AccessLiver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma
Liver cancer stem cells (LCSCs) play an important role in hepatocellular carcinoma (HCC), but the mechanisms that link LCSCs to HCC metastasis remain largely unknown. This study aims to reveal the contribution...
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Article
An improved bi-objective salp swarm algorithm based on decomposition for green scheduling in flexible manufacturing cellular environments with multiple automated guided vehicles
Energy-awareness in the industrial sectors has become a global consensus in recent decades. Green scheduling is acknowledged as an effective weapon to reduce energy consumption in the industrial sectors. There...
