43 Result(s)
within
**ndan Wang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers
The development of Type I photosensitizers (PSs) is of great importance due to the inherent hypoxic intolerance of photodynamic therapy (PDT) in the hypoxic microenvironment. Compared to Type II PSs, Type I PS...
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Open AccessDomain wall magnetic tunnel junction-based artificial synapses and neurons for all-spin neuromorphic hardware
We report a breakthrough in the hardware implementation of energy-efficient all-spin synapse and neuron devices for highly scalable integrated neuromorphic circuits. Our work demonstrates the successful execut...
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Open AccessA negative feedback loop between TET2 and leptin in adipocyte regulates body weight
Ten-eleven translocation (TET) 2 is an enzyme that catalyzes DNA demethylation to regulate gene expression by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine, functioning as an essential epigenetic regul...
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Open AccessThe use of deep learning integrating image recognition in language analysis technology in secondary school education
This work aims to investigate the application of advanced deep learning algorithms and image recognition technologies to enhance language analysis tools in secondary education, with the goal of providing educa...
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Open AccessMolecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor
Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions. Antihistamines that target the histamine H1 receptor (H
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Open AccessAuthor Correction: Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete
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Open AccessUnraveling the whole genome DNA methylation profile of zebrafish kidney marrow by Oxford Nanopore sequencing
Zebrafish is a widely used model organism for investigating human diseases, including hematopoietic disorders. However, a comprehensive methylation baseline for zebrafish primary hematopoietic organ, the kidne...
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Open AccessForensic toxicokinetics of difenidol hydrochloride in vivo verified by practical lethal cases
A gas chromatography-mass spectrometry (GC–MS) method for the determination of difenidol hydrochloride in biological specimens has been developed. The method exhibited excellent recovery (> 90%) and precision ...
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Open AccessAn airway-to-brain sensory pathway mediates influenza-induced sickness
Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediat...
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Open AccessSpintronic leaky-integrate-fire spiking neurons with self-reset and winner-takes-all for neuromorphic computing
Neuromorphic computing using nonvolatile memories is expected to tackle the memory wall and energy efficiency bottleneck in the von Neumann system and to mitigate the stagnation of Moore’s law. However, an ide...
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Open AccessA secreted effector with a dual role as a toxin and as a transcriptional factor
Bacteria have evolved multiple secretion systems for delivering effector proteins into the cytosol of neighboring cells, but the roles of many of these effectors remain unknown. Here, we show that Yersinia pseudo...
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Open AccessPolyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete
Borrelia burgdorferi, the tick-transmitted spirochete agent of Lyme disease, has a highly segmented genome with a linear chromosome and various linear or circular plasmids. Here, by imaging several chromosomal lo...
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Open AccessOpposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
Interleukin-9 (IL-9)-producing CD4+ T helper cells (Th9) have been implicated in allergy/asthma and anti-tumor immunity, yet molecular insights on their differentiation from activated T cells, driven by IL-4 and ...
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Open AccessThe Chloranthus sessilifolius genome provides insight into early diversification of angiosperms
Most extant angiosperms belong to Mesangiospermae, which comprises eudicots, monocots, magnoliids, Chloranthales and Ceratophyllales. However, phylogenetic relationships between these five lineages remain uncl...
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Open AccessStudy on the prognosis predictive model of COVID-19 patients based on CT radiomics
Making timely assessments of disease progression in patients with COVID-19 could help offer the best personalized treatment. The purpose of this study was to explore an effective model to predict the outcome o...
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Open AccessSarcoma IL-12 overexpression facilitates NK cell immunomodulation
Interleukin-12 (IL-12) is an inflammatory cytokine that has demonstrated efficacy for cancer immunotherapy, but systemic administration has detrimental toxicities. Lentiviral transduction eliciting IL-12-produ...
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Open AccessRespiratory chain components are required for peptidoglycan recognition protein-induced thiol depletion and killing in Bacillus subtilis and Escherichia coli
Mammalian peptidoglycan recognition proteins (PGRPs or PGLYRPs) kill bacteria through induction of synergistic oxidative, thiol, and metal stress. Tn-seq screening of Bacillus subtilis transposon insertion librar...
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Open AccessClinically applicable histopathological diagnosis system for gastric cancer detection using deep learning
The early detection and accurate histopathological diagnosis of gastric cancer increase the chances of successful treatment. The worldwide shortage of pathologists offers a unique opportunity for the use of ar...
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Open AccessIdeal Cardiovascular Health Metrics on the New Occurrence of Peripheral Artery Disease: A Prospective Cohort Study in Northern China
Peripheral artery disease (PAD) is a common atherosclerotic disease which could lead to severe cardiovascular and cerebrovascular events. Previous studies have indicated the ideal cardiovascular health (ICVH) ...
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Open AccessInhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren’s Syndrome
Cathepsin S (CTSS) is highly increased in Sjögren’s syndrome (SS) patients tears and in tears and lacrimal glands (LG) of male non-obese diabetic (NOD) mice, a murine model of SS. To explore CTSS’s utility as ...
