103 Result(s)
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Article
Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
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Compositional plasticity of the Atg1 complex
How do metabolic stresses trigger catabolic autophagy for cell survival? A study now reveals that the metabolite sensor Pho81 integrates into and activates the kinase activity of the Atg1 complex for pexophagy...
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Open AccessNon-mitotic proliferation of malignant cancer cells revealed through live-cell imaging of primary and cell-line cultures
Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-c...
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FUS maintains TAZ fluidity and function
The transcriptional coactivators TAZ and YAP pair with transcriptional enhanced associate domains (TEADs) to regulate transcription. TAZ and YAP nuclear condensates ensure optimal transcription. A new study re...
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Iron drives anabolic metabolism through active histone demethylation and mTORC1
All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here we report a previously u...
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KDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1, NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually exclusive, but recent evidence shows intra...
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Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development
Oxidative stress contributes to tumourigenesis by altering gene expression. One accompanying modification, 8-oxoguanine (o8G) can change RNA–RNA interactions via o8G•A base pairing, but its regulatory roles remai...
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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating innate sensing and adaptive immune...
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Open AccessDynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication for fork stability is poorly understood. Here we discover a...
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PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma
PBRM1 encodes an accessory subunit of the PBAF SWI/SNF chromatin remodeller, and the inactivation of PBRM1 is a frequent event in kidney cancer. However, the impact of PBRM1 loss on chromatin remodelling is not w...
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Frontiers in biomolecular condensate research
Biomolecular condensation of macromolecules is an increasingly important concept in cell biology. Indeed, research on condensates touches on multiple areas of research, from biochemistry to biophysics and from...
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METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus. Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its function is not fully understood. He...
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N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition
N6-methyladenosine (m6A) and its regulatory components play critical roles in various developmental processes in mammals. However, the landscape and function of m6A in early embryos remain unclear owing to limite...
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Open AccessPan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR ends via alternative polyadenylation c...
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The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster
Mitochondrial DNA (mtDNA) replication and transcription are of paramount importance to cellular energy metabolism. Mitochondrial RNA polymerase is thought to be the primase for mtDNA replication. However, it i...
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PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis
The accumulation of lipid peroxides is recognized as a determinant of the occurrence of ferroptosis. However, the sensors and amplifying process of lipid peroxidation linked to ferroptosis remain obscure. Here...
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Open AccessROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs
Reactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and redox sensing. ROMO1 regulates ROS generation with...
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Machinery, regulation and pathophysiological implications of autophagosome maturation
Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby cytosolic materials are sequestered in a double-membrane autophagosome and subsequently delivered to lysosomes, where th...
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Open AccessRal GTPase is essential for actin dynamics and Golgi apparatus distribution in mouse oocyte maturation
Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane tran...
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AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1
The sympathetic nervous system–catecholamine–uncoupling protein 1 (UCP1) axis plays an essential role in non-shivering adaptive thermogenesis. However, whether there exists a direct effector that physically co...
