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  1. Article

    Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

    Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes ...

    Deirdre K. Tobias, Jordi Merino, Abrar Ahmad, Catherine Aiken… in Nature Medicine (2023)

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    Article

    First-line pyrotinib in advanced HER2-mutant non-small-cell lung cancer: a patient-centric phase 2 trial

    To explore targeted treatment options in patients with non-small-cell lung cancer (NSCLC) with rare genetic mutations in the context of a patient-centric clinical trial, we initiated, in parallel, a phase 2 ad...

    Si-Yang Maggie Liu, Hai-Yan Tu, Xue-Wu Wei, Hong-Hong Yan… in Nature Medicine (2023)

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    The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment

    Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequ...

    Jiawei Lv, Yuan Wei, Jian-Hua Yin, Yu-Pei Chen, Guan-Qun Zhou, Chen Wei… in Nature Medicine (2023)

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    Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

    For decades, variability in clinical efficacy of the widely used inflammatory bowel disease (IBD) drug 5-aminosalicylic acid (5-ASA) has been attributed, in part, to its acetylation and inactivation by gut mic...

    Raaj S. Mehta, Jared R. Mayers, Yancong Zhang, Amrisha Bhosle… in Nature Medicine (2023)

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    Article

    Comprehensive plasma metabolomics and lipidomics of benign and malignant solitary pulmonary nodules

    Solitary pulmonary nodules (SPNs) are commonly found in imaging technologies, but are plagued by high false-positive rates.

    Wei Zhou, Lili Lin, Lian-yong Jiang, **-long Wu, Wei-chen Xu, Yang Zhou… in Metabolomics (2022)

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    Article

    Identification of a new orthonairovirus associated with human febrile illness in China

    The genus Orthonairovirus, which is part of the family Nairoviridae, includes the important tick-transmitted pathogens Crimean–Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other ...

    Jun Ma, **ao-Long Lv, Xu Zhang, Shu-Zheng Han, Ze-Dong Wang, Liang Li… in Nature Medicine (2021)

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    Article

    Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

    Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. We analyzed the expression profiles of HCC sa...

    Qing-Hai Ye, Lun-**u Qin, Marshonna Forgues, ** He, ** Woo Kim… in Nature Medicine (2003)