17 Result(s)
-
Article
Open AccessAmino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice
H7N9 subtype avian influenza viruses (AIVs) cause 1567 human infections and have high mortality, posing a significant threat to public health. Previously, we reported that two avian-derived H7N9 isolates (A/ch...
-
Article
Open AccessComparative policy analysis of national rare disease funding policies in Australia, Singapore, South Korea, the United Kingdom and the United States: a sco** review
Rare diseases pose immense challenges for healthcare systems due to their low prevalence, associated disabilities, and attendant treatment costs. Advancements in gene therapy, such as treatments for Spinal Mus...
-
Article
Open AccessDevelo** a production workflow for 3D-printed temporal bone surgical simulators
3D-printed temporal bone models enable the training and rehearsal of complex otological procedures. To date, there has been no consolidation of the literature regarding the developmental process of 3D-printed ...
-
Article
Open AccessPredicting factors for acute encephalopathy in febrile seizure children with SARS-CoV-2 omicron variant: a retrospective study
SARS-CoV-2 posed a threat to children during the early phase of Omicron wave because many patients presented with febrile seizures. The study aimed to investigate predicting factors for acute encephalopathy of...
-
Article
The economic burden of inherited retinal disease in Singapore: a prevalence-based cost-of-illness study
To assess the economic impact of inherited retinal disease (IRD) among Singaporeans.
-
Article
Open AccessComparative study on main compounds and hypoglycemic effects of dispensing granules of Coptidis Rhizoma and Scutellaria–Coptis herb couple with traditional decoction
The clinical applications of dispensing granules (DG) have increased dramatically. However, it is controversial whether the DG has the same quality and efficacy compared with traditional decoction (TD). In thi...
-
Article
Open AccessTargeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats
The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erbα in ischemia-reper...
-
Article
Open AccessA novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example
The oral bioavailability and blood–brain barrier permeability of many herbal products are too low to explain the significant efficacy fully. Gut microbiota and liver can metabolize herbal ingredients to more a...
-
Article
Two patients with KDM3B variants and new presentations of Diets–Jongmans syndrome
KDM3B is located on chromosome 5q31 and encodes KDM3B, which is involved in histone demethylation and epigenetic regulation. Pathogenic KDM3B variants cause a dominantly inherited disorder presenting with intelle...
-
Article
Open AccessLocally invasive recurrence or metastasis of pheochromocytoma into the liver?—clinicopathological challenges
Pheochromocytomas (PCC) are rare and functional neuroendocrine tumors develo** from adrenal chromaffin cells. Predicting malignant behavior especially in the absence of metastasis can be quite challenging ev...
-
Article
Open AccessA novel nonsense variant of the AGXT identified in a Chinese family: special variant research in the Chinese reference genome
Primary hyperoxaluria(PH)is a rare autosomal recessive genetic disease that contains three subtypes (PH1, PH2 and PH3). Approximately 80% of PH patients has been reported as subtype PH1, this subtype of PH has...
-
Article
Identification of prognostic claudins signature in hepatocellular carcinoma from a hepatocyte differentiation model
Loss of terminal differentiation markers and gain of stem cell-like properties are a major hallmark of cancer malignant progression. Identification of novel biomarkers representing tumor developmental progeny ...
-
Article
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway
This study aimed to verify the effects of berberine (BBR) on the fat metabolism proteins involved in the sirtuin 3 (SIRT3)/adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK)/acetyl-CoA carboxylas...
-
Article
Open AccessTargeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats
Emerging evidence reveals that nicotinamide phosphoribosyltransferase (NAMPT) has a significant role in the pathophysiology of the inflammatory process. NAMPT inhibition has a beneficial effect in the treatmen...
-
Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
-
Article
Open AccessCalcified, minimally Fat-contained angiomyolipoma clinically indistinguishable from a renal cell carcinoma
Angiomyolipomas are benign tumors of the kidney. Typical angiomyolipomas are usually recognized by identifying fat components before any intervention. On the contrary, solid renal masses without evident fatty ...
-
Article
The use of focus groups in evaluating quality of life components among elderly Chinese people
In Taiwan, to measure the quality of life (QOL) of elderly Chinese, one must rely on instruments developed in other Chinese or Western populations and not specifically for the elderly. The purpose of this stud...
