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Article
Open AccessNeferine inhibits BMECs pyroptosis and maintains blood–brain barrier integrity in ischemic stroke by triggering a cascade reaction of PGC-1α
Blood–brain barrier disruption is a critical pathological event in the progression of ischemic stroke (IS). Most studies regarding the therapeutic potential of neferine (Nef) on IS have focused on neuroprotect...
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Article
Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment
The buildup of plaques in atherosclerosis leads to cardiovascular events, with chronic unresolved inflammation and overproduction of reactive oxygen species (ROS) being major drivers of plaque progression. Nan...
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Article
The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a challenging treatment landscape, due to its complex pathogenesis and limited availability of clinical drugs. Ferroptosis, an iron-...
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Article
Tough Semi-interpenetrating Polyvinylpyrrolidone/Polyacrylamide Hydrogels Enabled by Bioinspired Hydrogen-bonding Induced Phase Separation
Semi-interpenetrating (semi-IPN) hydrogels formed by the continuous interpenetration of cross-linked polymer network and linear non-crosslinked polymer with multifunctionality are widely used in biomedical and...
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Article
Acoustic emission characteristics in tensile-shear failure of non-persistent jointed rocks with different undulation angles
Tensile-shear failure commonly occurs during the construction of deep in-situ tunnels. In this paper, direct tensile-shear tests were conducted on rock-like specimens containing regular serrated joints using a...
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Article
Open AccessDeficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice
Neutral cholesterol ester hydrolase 1 (NCEH1) plays a critical role in the regulation of cholesterol ester metabolism. Deficiency of NCHE1 accelerated atherosclerotic lesion formation in mice. Nonetheless, the...
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Article
Open AccessEvaluation of disease severity and prediction of severe cases in children hospitalized with influenza A (H1N1) infection during the post-COVID-19 era: a multicenter retrospective study
The rebound of influenza A (H1N1) infection in post-COVID-19 era recently attracted enormous attention due the rapidly increased number of pediatric hospitalizations and the changed characteristics compared to...
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Article
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy prone to recurrence and metastasis. Studies show that tumor cells with increased invasive and metastatic potential are more likely ...
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Article
Nanocavity enriched CuPd alloy with high selectivity for CO2 electroreduction toward C2H4
Electrocatalysis of CO2 reduction reaction is an effective way to convert CO2 into high value-added products, but the selectivity of Cu-based catalysts for C2+ products needs to be improved due to the high energy...
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Article
Argon non-thermal plasma treatment promotes the development of rice (Oryza sativa L.) in saline alkali environments
Soil salinization leads to a reduction in arable land area, which seriously endangers food security. Develo** saline-alkali land has become a key measure to address the contradiction between population growt...
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Article
Open AccessIndividualized atomoxetine response and tolerability in children with ADHD receiving different dosage regimens: the need for CYP2D6 genoty** and therapeutic drug monitoring to dance together
Integrating CYP2D6 genoty** and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retr...
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Article
Open AccessFractal analysis of left ventricular trabeculae in post-STEMI: from acute to chronic phase
The temporal evolution of ventricular trabecular complexity and its correlation with major adverse cardiovascular events (MACE) remain indeterminate in patients presenting with acute ST elevation myocardial in...
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Article
Computational markers of risky decision-making predict for relapse to alcohol
Relapse remains the major challenge in treatment of alcohol use disorder (AUD). Aberrant decision-making has been found as important cognitive mechanism underlying relapse, but factors associated with relapse ...
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Article
Open AccessLow pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides
Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric ef...
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Article
Unbound \(^{28}\) O, the heaviest oxygen isotope observed: a cutting-edge probe for testing nuclear models
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Article
Retraction Note: A New Cu(II)-Based Metal–Organic Framework for Highly Selective C2H2/C2H4 Separation and Prevention Against Carcinogenesis of Cirrhosis via Down-Regulating the CXCR3 Mediated Inflammatory Pathway
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Article
Open AccessDifferentiated genomic footprints suggest isolation and long-distance migration of Hmong-Mien populations
The underrepresentation of Hmong-Mien (HM) people in Asian genomic studies has hindered our comprehensive understanding of the full landscape of their evolutionary history and complex trait architecture. South...
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Article
Open AccessPrediction of positive pulmonary nodules based on machine learning algorithm combined with central carbon metabolism data
Lung cancer causes a huge disease burden, and early detection of positive pulmonary nodules (PPNs) as an early sign of lung cancer is extremely important for effective intervention. It is necessary to develop ...
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Article
Open AccessThe transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3
The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process an...
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Article
Open AccessNon-thermal plasma enhances rice seed germination, seedling development, and root growth under low-temperature stress
Recently, non-thermal plasma (NTP) technologies have found widespread application across diverse fields, including plant growth, medical science, and biological and environmental research. Rice (Oryza sativa L.) ...
