1,501 Result(s)
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**n-Fu Wang
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Article
Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
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Open AccessGenetic diversity and prevalence of emerging Rickettsiales in Yunnan Province: a large-scale study
Rickettsia and related diseases have been identified as significant global public health threats. This study involved comprehensive field and systematic investigations of various rickettsial organisms in Yunna...
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Open AccessPerturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging
Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity...
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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Bi2O3/g-C3N4 hollow core–shell Z-scheme heterojunction for photocatalytic uranium extraction
Photocatalytic uranium extraction from radioactive nuclear wastewater and seawater is critical for promoting the sustainable advancement of nuclear industry, but the complexity of real-world environments, part...
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Early detection of anthracycline-induced cardiotoxicity using [68 Ga]Ga-FAPI-04 imaging
Anthracycline-induced cardiotoxicity (AIC), whose major manifestation is diffuse myocardial fibrosis, is an important clinical problem in cancer therapy. Therefore, early identification and treatment are clini...
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Open AccessStomach as the target organ of Rickettsia heilongjiangensis infection in C57BL/6 mice identified by click chemistry
Spotted fever group rickettsiae (SFGR) are obligate intracellular bacteria that cause spotted fever. The limitations of gene manipulation pose great challenges to studying the infection mechanisms of Rickettsia. ...
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Open AccessEnhancing hepatocellular carcinoma management: prognostic value of integrated CCL17, CCR4, CD73, and HHLA2 expression analysis
Hepatocellular carcinoma (HCC) is a critical global health concern, with existing treatments benefiting only a minority of patients. Recent findings implicate the chemokine ligand 17 (CCL17) and its receptor C...
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Open Access0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period
3% chloroprocaine (CP) has been reported as the common local anesthetic used in pregnant women undergoing urgent cesarean delivery during labor analgesia period. However, 0.75% ropivacaine is considered a prom...
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Open AccessA trait-based root acquisition-defence-decomposition framework in angiosperm tree species
To adapt to the complex belowground environment, plants make trade-offs between root resource acquisition and defence ability. This includes forming partnerships with different types of root associating microo...
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Open AccessReciprocal regulation between RACGAP1 and AR contributes to endocrine therapy resistance in prostate cancer
Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activat...
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Hybrid pseudocapacitance/co-intercalation mechanisms of TiO2/graphite anodes for rapid sodium-ion storage
Develo** anode materials with high specific/volumetric capacities, high-rate capability, long-term cycles and low cost is significant for advanced sodium-ion storage. Herein, we report the hybrid TiO2/graphite ...
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Open AccessType 2 Biomarkers and Their Clinical Implications in Bronchiectasis: A Prospective Cohort Study
Bronchiectasis is predominantly marked by neutrophilic inflammation. The relevance of type 2 biomarkers in disease severity and exacerbation risk is poorly understood. This study explores the clinical signific...
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Open AccessBone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteo...
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Open AccessFarnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using ...
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Open AccessPoly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity
Post-transcriptional regulation of cytokine/chemokine mRNA turnover is critical for immune processes and contributes to the mammalian cellular response to diverse inflammatory stimuli. The ubiquitous RNA-bindi...
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Effects of nanographene oxide on adipose-derived stem cell cryopreservation
Cryoinjury mitigation is key in cell cryopreservation. Here, we aimed to assess the effectiveness of nanographene oxide (nano-GO) for improving cryoprotectant agents (CPAs) in human adipose stem cell (hADSC) c...
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Open AccessBacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence
Bacteriophage are sophisticated cellular parasites that can not only parasitize bacteria but are increasingly recognized for their direct interactions with mammalian hosts. Phage adherence to mucus is known to...
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Federated learning for feature-fusion based requirement classification
With the increasing complexity of products, the utilization of automated requirements classification in the process of requirement engineering is of positive significance to improve the efficiency of product d...
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Partitioning of pore space in hydrogen-bonded organic frameworks for enhanced CO2 photoreduction
Hydrogen-bonded organic frameworks (HOFs) hold significant promise for catalytic applications. However, the collapse of pores upon solvent removal significantly restricts the utility of HOFs in photocatalytic ...
