17 Result(s)

Article

Detection of clinically significant prostate cancer following initial omission of biopsy in multiparametric MRI era

Multiparametric prostate MRI (mpMRI) is being increasingly adopted for work-up of prostate cancer. For patients selected to omit biopsy, we identified factors associated with repeat MRI, eventual prostate biop...

Eric V. Li, Anna M. Busza, Mohammad R. Siddiqui… in Prostate Cancer and Prostatic Diseases (2024)

Article

A method for noninvasive electrical stimulation of the diaphragm

Stimulated contraction of the diaphragm by non-invasive electrical stimulation of the phrenic nerve is demonstrated. A specialized device including a programmable current source and an electrode system has bee...

A. A. Akhmetova, S. V. Shapovalov, R. V. Li, S. S. Smirnov… in Biomedical Engineering (2024)

Article

A device for non-invasive electrical stimulation of the phrenic nerve

Results obtained from studies of the development of a device for non-invasive electrical stimulation of the phrenic nerve are presented. A block diagram of the device and schematics of key functional blocks ar...

R. V. Li, N. N. Potrakhov, A. A. Ukhov, S. V. Shapovalov… in Biomedical Engineering (2024)

Article

Optimizing detection of clinically significant prostate cancer through nomograms incorporating mri, clinical features, and advanced serum biomarkers in biopsy naïve men

To develop nomograms that predict the detection of clinically significant prostate cancer (csPCa, defined as ≥GG2 [Grade Group 2]) at diagnostic biopsy based on multiparametric prostate MRI (mpMRI), serum biom...

Mohammad R. Siddiqui, Eric V. Li… in Prostate Cancer and Prostatic Diseases (2023)

Article

Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

Comprehensive enhancer discovery is challenging because most enhancers, especially those contributing to complex diseases, have weak effects on gene expression. Our gene regulatory network modeling identified ...

Renhe Luo, Jielin Yan, ** Woo Oh, Wang **, Dustin Shigaki, Wilfred Wong… in Nature Genetics (2023)

Article

Real-world use of MRI for risk stratification prior to prostate biopsy

The utilization of MRI to risk stratify elevated PSA prior to prostate biopsy has been inconsistently adopted and varies considerably by practice setting. This study aims to evaluate the usage and performance ...

Mohammad R. Siddiqui, Brandon Ansbro… in Prostate Cancer and Prostatic Diseases (2023)

Article

A transcriptomic model for homologous recombination deficiency in prostate cancer

Tumors with mutations associated with homologous recombination deficiency (HRD) are uncommon in prostate cancer (PCa) and variably responsive to PARP inhibition. To better identify tumors with HRD, we develope...

Adam B. Weiner, Yang Liu, Matthew McFarlane… in Prostate Cancer and Prostatic Diseases (2022)

Article

Comparative Proteomic Analysis of the Mycoplasma gallisepticum Nucleoid Fraction before and after Infection

Mycoplasma gallisepticum belongs to the class Mollicutes and induces severe chronic respiratory disease in chickens. It lacks the cell wall and contains a very small genome and, accordingly, a reduced set of reg...

M. A. Galyamina, A. I. Zubov, V. G. Ladygina… in Bulletin of Experimental Biology and Medic… (2022)

Article

Survival following upfront chemotherapy for treatment-naïve metastatic prostate cancer: a real-world retrospective cohort study

Upfront chemotherapy prolongs overall survival for men with metastatic, hormone-sensitive prostate cancer (mHSPC) based on data from clinical trials. We sought to assess the association between upfront chemoth...

Adam B. Weiner, Oliver S. Ko, Eric V. Li… in Prostate Cancer and Prostatic Diseases (2021)

Article

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highli...

Qing V. Li, Gary Dixon, Nipun Verma, Bess P. Rosen, Miriam Gordillo… in Nature Genetics (2019)

Article

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output ...

Nipun Verma, Heng Pan, Louis C. Doré, Abhijit Shukla, Qing V. Li… in Nature Genetics (2018)

Article

Vaccine delivery with microneedle skin patches in nonhuman primates

Peter C DeMuth, Adrienne V Li, Peter Abbink, **yan Liu, Hualin Li… in Nature Biotechnology (2013)

Article

Characterization of data analysis methods for information recovery from metabolic ¹H NMR spectra using artificial complex mixtures

The assessment of data analysis methods in ¹H NMR based metabolic profiling is hampered owing to a lack of knowledge of the exact sample composition. In this study, an artificial complex mixture design comprising...

Alexessander C. Alves, Jia V. Li, Isabel Garcia-Perez, Caroline Sands… in Metabolomics (2012)