6,147 Result(s)
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**n Tian
Life Sciences
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Article
Open Accessβ-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
To explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), and to investigate the underlying mechanism...
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Hydroxy Selenomethionine Exert Different Protective Effects Against Dietary Oxidative Stress–Induced Inflammatory Responses in Spleen and Thymus of Pigs
Oxidative stress (OS) is widespread in animal husbandry, which causes edema in immune organs and suppresses immune function of animals. Selenium (Se) is an essential trace element involved in immune regulation...
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The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs
Physical activity on a regular basis has been shown to bolster the overall wellness of an individual; research is now revealing that these changes are accompanied by epigenetic modifications. Regular exercise ...
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Changes of gut microbiota diversity and stability over the reproduction process in captive female Gentoo penguins (Pygoscelis papua)
Homeostasis of gut microbiota is critical for growth and health of animals. However, the impact of reproduction on penguin gut microbiota remains unclear, despite penguins being sentinel species of the marine ...
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The genetic architecture of biological age in nine human organ systems
Investigating the genetic underpinnings of human aging is essential for unraveling the etiology of and develo** actionable therapies for chronic diseases. Here, we characterize the genetic architecture of th...
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Author Correction: Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality
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Open AccessTesting the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim
Healthy Longevity Medicine aims to optimize health by targeting aging processes across the lifespan. Addressing accelerated aging involves adaptation of lifestyle and the use of geroprotective drugs and supple...
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Open AccessGmHXK2 promotes the salt tolerance of soybean seedlings by mediating AsA synthesis, and auxin synthesis and distribution
Salt is an important factor that affects crop productivity. Plant hexokinases (HXKs) are key enzymes in the glycolytic pathway and sugar signaling transduction pathways of plants. In previous studies, we ident...
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A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion
Cargo translocation across membranes is a crucial aspect of secretion. In conventional secretion signal peptide-equipped proteins enter the endoplasmic reticulum (ER), whereas a subset of cargo lacking signal ...
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Open AccessBiosynthesis of cupric oxide nanoparticles: its antiviral activities against TMV by directly destroying virion and inducing plant resistance
Tobacco mosaic virus (TMV) is widely recognized as one of the most important plant viruses, causing significant agricultural losses in terms of both quality and yield worldwide each year. This study demonstrat...
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Effects of warming on litter decomposition and fungal communities in lake wetlands
The impact of climate warming on the decomposition of wetland plant litter has received widespread attention. We used the litter bag method to compare and study the decomposition processes of three species of ...
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Effects of temperature and salinity on indoor preservation of in vitro holdfast of Sargassum fusiforme
Cryopreservation of receptacles or fertilized eggs is the main method for the preservation of indoor germplasm resources for the economic seaweed Sargassum fusiforme. However, none of these methods can achieve lo...
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Open AccessThe relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hyperuricaemia
The ratio of non-high-density lipoprotein cholesterol (non-HDL-c) to high-density lipoprotein cholesterol (HDL-c) (NHHR) is a novel comprehensive lipid index. The aim of this study was to investigate the relat...
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Open AccessIL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease
Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorde...
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Open AccessGenome-wide identification of ATG genes and their expression profiles under biotic and abiotic stresses in Fenneropenaeus chinensis
Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. Extensive research has shown that autophagy pl...
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Nuclear translocation of β-catenin and migration of arecoline-induced oral cancer cells reduced by Taiwanin E via p-GSK3β downregulation
Oral squamous cell carcinomas (OSCCs) accounts for 90% of the total oral cancers and is a major public health issue worldwide. It is the most prevalent malignant epithelial neoplasm of the oral cavity.
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Optimizing Nitrogen Fertilization Managements Under Mechanical Deep Placement for Raising Rice Grain Yield
It is not known whether both reducing tiller-fertilizer and increasing panicle-fertilizer can significantly increase grain yield under mechanical deep placement. The two-year field experiment was conducted to ...
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Open AccessCross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health
Throughout the life span of a host, bifidobacteria have shown superior colonization and glycan abilities. Complex glycans, such as human milk oligosaccharides and plant glycans, that reach the colon are direct...
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Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
