32 Result(s)

Chapter

Contrast-Enhanced MRI and Micro-CT Adopted for Evaluation of a Lipid-Lowering and Anticoagulant Herbal Epimedium-Derived Phytoestrogenic Extract for Prevention of Steroid-Associated Osteonecrosis

We developed an alternative steroid-associated osteonecrosis (ON) rabbit model using a combination of a single injection of low-dose lipopolysaccharide (LPS) and three subsequent injections of pulsed high-dose...

Ling Qin, Ge Zhang, Hui Sheng… in Advanced Bioimaging Technologies in Assess… (2007)

Article

Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development

Increased bone marrow lipid deposition in steroid-associated osteonecrosis (ON) implies that abnormalities in fat metabolism play an important role in ON development. The increase in lipid deposition might be ...

Hui Sheng, Ge Zhang, Wing Cheung, Chun Chan… in Journal of Orthopaedic Surgery and Research (2007)

Article

Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

This study was performed to evaluate the attenuation of osteoarthritic (OA) pathogenesis via disruption of the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) signaling with AMD31...

Fangyuan Wei, Douglas C Moore, Yanlin Li, Ge Zhang… in Arthritis Research & Therapy (2012)

Article

Erratum to: Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

Fangyuan Wei, Douglas C Moore, Lei Wei, Yanlin Li, Ge Zhang… in Arthritis Research & Therapy (2013)

Article

Erythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditions

Erythropoietin (EPO) provides an alternative to transfusion for increasing red blood cell mass and treating anemia in cancer patients. However, recent studies have reported increased adverse events and/or redu...

Makito Miyake, Steve Goodison, Adrienne Lawton… in Journal of Hematology & Oncology (2013)

Article

Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreER ^T2 ; Ihh^fl/^fl mice

Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, ther...

**gming Zhou, Qian Chen, Beate Lanske, Braden C Fleming… in Arthritis Research & Therapy (2014)

Article

Exosomes: an overview of biogenesis, composition and role in ovarian cancer

Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such a...

Allison Beach, Huang-Ge Zhang, Mariusz Z Ratajczak… in Journal of Ovarian Research (2014)

Article

Fei-Liu-** ointment inhibits lung cancer growth and invasion by suppressing tumor inflammatory microenvironment

Lung cancer is one of the leading causes of cancer-related mortality worldwide. Conventional chemotherapy and radiotherapy are the primary therapeutic methods for lung cancer with the use of combination therap...

Weidong Li, Cihui Chen, Shakir M Saud… in BMC Complementary and Alternative Medicine (2014)

Article

Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature

To validate the expression of a urine-based bladder cancer associated diagnostic signature comprised of 10 targets; ANG, CA9, MMP9, MMP10, SERPINA1, APOE, SDC1, VEGFA, SERPINE1 and IL8 in bladder tumor tissues.

Ge Zhang, Evan Gomes-Giacoia, Yunfeng Dai, Adrienne Lawton… in Diagnostic Pathology (2014)

Article

Virtual screening of the inhibitors targeting at the viral protein 40 of Ebola virus

The Ebola virus is highly pathogenic and destructive to humans and other primates. The Ebola virus encodes viral protein 40 (VP40), which is highly expressed and regulates the assembly and release of viral par...

V. Karthick, N. Nagasundaram, C. George Priya Doss… in Infectious Diseases of Poverty (2016)

Article

Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014

The objective of this study was to investigate the distribution and susceptibility of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with UTIs collected within 48 h (community acq...

Qiwen Yang, Hui Zhang, Yao Wang, Zhipeng Xu, Ge Zhang… in BMC Infectious Diseases (2017)

Article

Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial

Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations ...

Chi Zhang, Daogang Guan, Miao Jiang, Chao Liang, Li Li, Ning Zhao… in Chinese Medicine (2019)

Article

Ultrasonography-guided closed reduction in the treatment of displaced transphyseal fracture of the distal humerus

To evaluate the clinical and radiographic outcomes of ultrasonography-guided closed reduction in the treatment of displaced transphyseal fracture of the distal humerus (TFDH).

Hai Zhou, Ge Zhang, Ming Li, **angyang Qu… in Journal of Orthopaedic Surgery and Research (2020)

Article

Efficacy of closed reduction for developmental dysplasia of the hip: midterm outcomes and risk factors associated with treatment failure and avascular necrosis

The purpose of this study was to evaluate the efficacy of closed reduction (CR) in the treatment of developmental dysplasia of the hip (DDH) and to investigate risk factors associated with CR failure and avasc...

Ge Zhang, Ming Li, **angyang Qu, Yujiang Cao… in Journal of Orthopaedic Surgery and Research (2020)

Article

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...

**ao-Yue Hong, Hua-Li Wan, Ting Li… in Signal Transduction and Targeted Therapy (2020)

Article

Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...

Xuekun Fu, Bo Zhou, Qinnan Yan, Chu Tao… in Signal Transduction and Targeted Therapy (2020)

Article

Trans-scapular approach coil localization for scapular-blocked pulmonary nodules: a retrospective study

Preoperative computed tomography (CT)-guided coil localization (CL) is commonly used to facilitate video-assisted thoracoscopic surgery (VATS)-guided diagnostic wedge resection (WR) of pulmonary nodules (PNs)....

Juan Wu, Min-Ge Zhang, ** Chen, Wen-Bin Ji in Journal of Cardiothoracic Surgery (2021)

Article

The role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance

Sphingomyelin (SM) is an essential component of biological lipid rafts, and it plays an indispensable role in maintaining plasma membrane stability and in mediating signal transduction. The ultimate biosynthes...

Yifan Guo, Lin Chang, Ge Zhang, Zhanyan Gao, Hao Lin, Yuting Zhang… in Thrombosis Journal (2021)

Article

Neurological and psychiatric presentations associated with COVID-19

The objective is to investigate coronavirus disease 2019 (COVID-19)-associated neurological and psychiatric effects and explore possible pathogenic mechanisms. This study included 77 patients with laboratory-c...

Xudong He, Dan Zhang, Lei Zhang, Xu Zheng… in European Archives of Psychiatry and Clinic… (2022)

Article

Learning to predict in-hospital mortality risk in the intensive care unit with attention-based temporal convolution network

Dynamic prediction of patient mortality risk in the ICU with time series data is limited due to high dimensionality, uncertainty in sampling intervals, and other issues. A new deep learning method, temporal co...

Yu-wen Chen, Yu-jie Li, Peng Deng, Zhi-yong Yang, Kun-hua Zhong… in BMC Anesthesiology (2022)