408 Result(s)
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Article
Open AccessEnhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4
Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties. However, the poor water solubility of OBB hinders its release and absorption thus resulting in low bioavailabil...
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Open AccessEvaluation of the outcomes of biliary-enteric reconstruction in robotic radical resection of hilar cholangiocarcinoma: a single-center propensity score matching analysis
Although robotic radical resection for hilar cholangiocarcinoma (HCCA) has been reported in some large hepatobiliary centers, biliary-enteric reconstruction (BER) remains a critical step that hampers the opera...
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Open AccessThe protective effect of physical activity on mental health of middle school students at different stages during the COVID-19 outbreak
This study aims to further understand the changes in physical activity level(PAL) and mental health among adolescents before and after the outbreak of COVID-19 and explore the protective role of physical activ...
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Open AccessDeep learning model for the prediction of all-cause mortality among long term care people in China: a prospective cohort study
This study aimed to develop a deep learning model to predict the risk stratification of all-cause death for older people with disability, providing guidance for long-term care plans. Based on the government-le...
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Open AccessComparison of tacrolimus with or without prednisone therapy in primary membranous nephropathy: a retrospective clinical study
Previous studies showed tacrolimus monotherapy and dual therapy with tacrolimus and prednisone as effective treatment modalities in managing membranous nephropathy. However, few studies have compared these the...
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Open AccessSDWPF: A Dataset for Spatial Dynamic Wind Power Forecasting over a Large Turbine Array
Wind power is a clean and renewable energy, yet it poses integration challenges to the grid due to its variable nature. Thus, Wind Power Forecasting (WPF) is crucial for its successful integration. However, ex...
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Open AccessPrevalence and relevant factors of nocturia and its impact on sleep quality in Chinese university students
The purpose of this study was to investigate the prevalence and relevant factors of nocturia and its impact on sleep quality in university students in Mainland China. A large-scale survey was conducted on 14,0...
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Open AccessSingle-molecule reconstruction of eukaryotic factor-dependent transcription termination
Factor-dependent termination uses molecular motors to remodel transcription machineries, but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we use single-molecule fluorescence...
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Open AccessRealization of monolayer ZrTe5 topological insulators with wide band gaps
Two-dimensional topological insulators hosting the quantum spin Hall effect have application potential in dissipationless electronics. To observe the quantum spin Hall effect at elevated temperatures, a wide b...
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Open AccessMicrobiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation
Innate lymphoid cell precursors (ILCPs) develop into distinct subsets of innate lymphoid cells (ILCs) with specific functions. The epigenetic program underlying the differentiation of ILCPs into ILC subsets re...
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Open AccessPostponed endoscopic necrosectomy results in a lower rate of additional intervention for infected walled-off necrosis
Although endoscopic necrosectomy (EN) is more frequently used to manage walled-off necrosis (WON), there is still debate over how much time should pass between the initial stent placement and the first necrose...
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Open AccessHigh-performance flexible p-type Ce-filled Fe3CoSb12 skutterudite thin film for medium-to-high-temperature applications
P-type Fe3CoSb12-based skutterudite thin films are successfully fabricated, exhibiting high thermoelectric performance, stability, and flexibility at medium-to-high temperatures, based on preparing custom target ...
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Open AccessDivacancy and resonance level enables high thermoelectric performance in n-type SnSe polycrystals
N-type polycrystalline SnSe is considered as a highly promising candidates for thermoelectric applications due to facile processing, machinability, and scalability. However, existing efforts do not enable a peak
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Open AccessInverted device architecture for high efficiency single-layer organic light-emitting diodes with imbalanced charge transport
Many wide-gap organic semiconductors exhibit imbalanced electron and hole transport, therefore efficient organic light-emitting diodes require a multilayer architecture of electron- and hole-transport material...
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Open AccessCBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway
Multiple studies have shown knockdown of chromobox 7 (CBX7) promotes the regenerative capacity of various cells or tissues. We examined the effect of CBX7 on hepatocyte proliferation and liver regeneration aft...
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Open AccessNonuniform and pathway-specific laminar processing of spatial frequencies in the primary visual cortex of primates
The neocortex comprises six cortical layers that play a crucial role in information processing; however, it remains unclear whether laminar processing is consistent across all regions within a single cortex. I...
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Open AccessStudy on the dynamic response characteristics of lining structures in large-section tunnel blasting using JH-2 model analysis
The lining structures of tunnels are typically constructed using sprayed or cast concrete materials, and their performance and quality during tunnel excavation and blasting are crucial for the stability and sa...
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Open AccessThe optimization method of wing plasma ice shape regulation based on quantitative assessment of flight risk
Plasma ice shape regulation is a technology which uses plasma actuator to regulate the continuous ice into safer intermittent ice by its significant thermal effect with limited energy. Whether plasma ice shape...
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Open AccessIn vivo genome editing via CRISPR/Cas9-mediated homology-independent targeted integration for Bietti crystalline corneoretinal dystrophy treatment
Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive chorioretinal degenerative disease without approved therapeutic drugs. It is caused by mutations in CYP4V2 gene, and about 80% of BCD pat...
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Airway hillocks are injury-resistant reservoirs of unique plastic stem cells
Airway hillocks are stratified epithelial structures of unknown function1. Hillocks persist for months and have a unique population of basal stem cells that express genes associated with barrier function and cell...
