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Article
Open AccessRegulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis
The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreat...
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Article
Open AccessReal-world evidence of a novel tetravalent immunoglobulin Y effectiveness and safety in patients with the refractory Helicobacter pylori infection
Refractory Helicobacter pylori (H. pylori) infection inevitably increase the difficulty of drug selection. Here, we described our experience with the use of a novel tetravalent IgY against H. pylori for the treat...
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Article
Open AccessLearning and depicting lobe-based radiomics feature for COPD Severity staging in low-dose CT images
Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating respiratory condition that imposes a significant healthcare burden worldwide. Accurate staging of COPD severity is crucial for patie...
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Article
Open AccessQL1209 (pertuzumab biosimilar) versus reference pertuzumab plus trastuzumab and docetaxel in neoadjuvant treatment for HER2-positive, ER/PR-negative, early or locally advanced breast cancer: A multicenter, randomized, double-blinded, parallel-controlled, phase III equivalence trial
This randomized, parallel-controlled, double-blinded, phase III equivalence study evaluated the equivalence of a proposed pertuzumab biosimilar QL1209 to the pertuzumab (Perjeta®) each with trastuzumab and doc...
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Article
Open AccessTree-Inspired Structurally Graded Aerogel with Synergistic Water, Salt, and Thermal Transport for High-Salinity Solar-Powered Evaporation
Inspired by transport system in trees, a two-way water and salt transport mechanism is realized in a structurally graded aerogel, enabling simultaneous fast water uptake and sa...
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Article
Antibiotic-free production of sucrose isomerase in Bacillus subtilis by genome integration
Sucrose isomerase (SIase) catalyzes the hydrolysis and isomerization of sucrose to form isomaltulose, a valuable functional sugar widely used in the food industry. However, the lack of safe and efficient heter...
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Article
Environmentally friendly zwitterionic fluorocarbon surfactant for high-efficiency emulsion polymerization of fluoropolymers
Fluorocarbon surfactants are widely used, especially in the emulsion polymerization of fluoropolymers, due to their high surface activity, excellent stability, and excellent compatibility. However, the long-te...
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Article
High-efficiency Ce-modified ZSM-5 nanosheets for waste plastic upgrading
Zeolite-based catalyst hydrocracking of plastics is a potential strategy for mitigating the environmental impacts of plastic wastes and recycling valuable resources, but difficult mass transfer, low concentrat...
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Article
Strand-preferred base editing of organellar and nuclear genomes using CyDENT
Transcription-activator-like effector (TALE)-based tools for base editing of nuclear and organellar DNA rely on double-stranded DNA deaminases, which edit substrate bases on both strands of DNA, reducing editi...
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Article
Open AccessICDM-GEHC: identifying cancer driver module based on graph embedding and hierarchical clustering
Due to the high heterogeneity of cancers, it is rather essential to explore driver modules with the help of gene mutation data as well as known interactions between genes/proteins. Unfortunately, latent false ...
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Article
Finite or Infinite Spreading Speed of an Epidemic Model with Free Boundary and Double Nonlocal Effects
We determine the spreading speed of an epidemic model with nonlocal diffusion and free boundary. The model is evolved from a degenerate reaction-diffusion model of Capasso and Maddalena (J Math Biol 13:173–184...
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Article
Open AccessMolecular subtypes of breast cancer identified by dynamically enhanced MRI radiomics: the delayed phase cannot be ignored
To compare the diagnostic performance of intratumoral and peritumoral features from different contrast phases of breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) by building radiomics mode...
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Article
Surface Plasmon Resonance Sensor Based on Mn2O3/Au Structure for Detecting Monosodium Glutamate
Monosodium glutamate (MSG) is a commonly used seasoning in various culinary applications. However, excessive intake of monosodium glutamate can cause irreversible harm to the human body. Therefore, the detecti...
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Article
Open AccessA Soft Supernumerary Robotic Limb with Fiber-Reinforced Actuators
Supernumerary robotic limbs (SRLs) have great potentials to assist human in daily activities and industrial manufacturing by providing extra limbs. However, current SRLs have heavy and rigid structures that ma...
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Article
A novel water-soluble quinoxalino[2,3-a] phenazine-based organic NIR photothermal agent for cancer phototherapy application
Organic near-infrared (NIR) photothermal agents have tremendous potential in cancer therapy. Herein we report anovel NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal...
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Article
Open AccessModified Lichong decoction intervenes in colorectal cancer by modulating the intestinal flora and the Wnt/β-catenin signaling pathway
The pathogenesis and treatment of colorectal cancer (CRC) continue to be areas of ongoing research, especially the benefits of traditional Chinese medicine (TCM) in slowing the progression of CRC. This study w...
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Article
Clinical and imaging evolution of cerebral amyloid angiopathy-related inflammation: a long follow-up case
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Article
Microbial infection promotes amyloid pathology in a mouse model of Alzheimer’s disease via modulating γ-secretase
Microbial infection as a type of environmental risk factors is considered to be associated with long-term increased risk of dementia, including Alzheimer’s disease (AD). AD is characterized by two neuropatholo...
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Article
Can the digital economy empower urban energy resource transition? A natural gas perspective
The diffusion effect of the digital economy (DEN) has become increasingly prominent, but few scholars have investigated the energy transition effect of China’s DEN. To this end, this study takes 207 cities in ...
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Article
High levels of soil calcium and clay facilitate the recovery and stability of organic carbon: Insights from different land uses in the karst of China
Soil organic carbon (SOC) is a crucial medium of the global carbon cycle and is profoundly affected by multiple factors, such as climate and management practices. However, interactions between different SOC fr...
