120 Result(s)

Article

Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease

Ubiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUB...

Liuyan Ding, Lin Lu, Shaohui Zheng, Zhiling Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Author Correction: Identification of an intraocular microbiota

Yuhua Deng, **aofei Ge, Yan Li, Bin Zou, **aofeng Wen, Weirong Chen… in Cell Discovery (2024)

Article

A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE

Research and development on Nectin-4 antibody-drug conjugates (ADC) have been greatly accelerated since the approval of enfortumab vedotin to treat uroepithelial cancer. During the course of this study, we ide...

Yichen Wang, Yanyang Nan, Chunguang Ma, **aolin Lu, Qian Wang… in Cell Death & Disease (2024)

Article

DANCE: a deep learning library and benchmark platform for single-cell analysis

DANCE is the first standard, generic, and extensible benchmark platform for accessing and evaluating computational methods across the spectrum of benchmark datasets for numerous single-cell analysis tasks. Cur...

Jiayuan Ding, Renming Liu, Hongzhi Wen, Wenzhuo Tang, Zhaoheng Li… in Genome Biology (2024)

Article

Tracking circulating PD-L1-positive cells to monitor the outcome of patients with gastric cancer receiving anti-HER2 plus anti-PD-1 therapy

Dual blockade of HER2 and PD-1/PD-L1 is the most promising regimen for HER2-positive patients with gastric cancer (GC); PD-L1 combined positive score, rather than HER2 status, indicates potential benefit. Circ...

**aoyi Chong, Yanyan Li, Jialin Lu, Xujiao Feng, Yilin Li, **aotian Zhang in Human Cell (2024)

Article

Maintenance of adult stem cells from human minor salivary glands via the Wnt signaling pathway

Xerostomia is a salivary gland dysfunction that negatively impacts the life quality of patients; however, there is no effective treatment for xerostomia. Bioengineered organs, generated using stem cells obtain...

Bo kyoung Kang, Zhu Zhu, Jian Wang, Jia Zhou, Shun Yu… in Stem Cell Research & Therapy (2023)

Article

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer

Lymphatic metastasis is the most common pattern of bladder cancer (BCa) metastasis and has an extremely poor prognosis. Emerging evidence shows that ubiquitination plays crucial roles in various processes of t...

Kanghua **ao, Shengmeng Peng, Junlin Lu, Ting Zhou, Xuwei Hong… in Cell Death & Disease (2023)

Article

Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration

Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. RPE s...

Wenchang Xu, **nqi Liu, Wenjuan Han, Keling Wu… in Cell Communication and Signaling (2023)

Article

Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance

It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveola...

Yu Zhang, Jun Zhou, Ling Hua, Pan Li, Jiaqi Wu… in Cell Communication and Signaling (2023)

Article

Improvement of straw decomposition and rice growth through co-application of straw-decomposing inoculants and ammonium nitrogen fertilizer

The growth of rice is reduced by the slow decomposition of accumulated straw, which competes with rice for soil nitrogen nutrient. In recent year, straw-decomposing inoculants (SDIs) that can accelerate straw ...

Wei Liu, Jichao Tang, Dahong Zhang, Xun Jiang, Bilin Lu, Wenjia Yang in BMC Plant Biology (2023)

Article

LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway

Our previous studies showed that dysregulation of the long noncoding RNA (lncRNA) HOXA11-AS plays an important role in the development of glioma. However, the molecular mechanism of HOXA11-AS in glioma remains...

Cheng Wei, **aoyang Zhang, Dazhao Peng, Xu Zhang, Haizhen Guo… in Cell Death & Disease (2022)

Article

HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1/SLC3A2 pathway

In patients with acute aortic dissection (AAD), increased vascular smooth muscle cell (VSMC) apoptosis has been found. Human cytomegalovirus (HCMV)-miR-US33-5p was significantly increased in the plasma of pati...

Jian Dong, Shuangshuang Li, Zilin Lu, Pengcheng Du… in Cellular & Molecular Biology Letters (2022)

Article

Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signaling

Chemoresistance often causes the failure of treatment and death of patients with advanced non-small-cell lung cancer. However, there is still no resistance genes signature and available enriched signaling deri...

Yujia Zhang, Fengjun Qiu, Tingjie Ye, Sau Har Lee… in Stem Cell Research & Therapy (2022)