41,113 Result(s)
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**li Li
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAuthor Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
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Open AccessMulti-omic characterization of allele-specific regulatory variation in hybrid pigs
Hybrid map** is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc and Lulai...
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Open AccessNBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically1,2. This results in substantial accumulation of lacate, the end...
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Open AccessResearch on the characteristics of electro-hydraulic position servo system of RBF neural network under fuzzy rules
A radial basis function neural network PID controller under fuzzy rules (FUZZY-RBF-PID) was designed for the electro-hydraulic position servo system under the influence of uncertain factors such as load mutati...
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Open AccessSpeculative culture and corporate high-quality development in China: mediating effect of corporate innovation
This paper associates the speculative culture with the corporate total factor productivity (TFP), aiming to explore the influence of speculative culture on corporate high-quality development. The results revea...
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Open AccessMiddle and Late Pleistocene Denisovan subsistence at Baishiya Karst Cave
Genetic and fragmented palaeoanthropological data suggest that Denisovans were once widely distributed across eastern Eurasia1–3. Despite limited archaeological evidence, this indicates that Denisovans were capab...
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Imaging tunable Luttinger liquid systems in van der Waals heterostructures
One-dimensional (1D) interacting electrons are often described as a Luttinger liquid1–4 having properties that are intrinsically different from those of Fermi liquids in higher dimensions5,6. In materials systems...
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Open AccessO-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhi...
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Open AccessUnraveling distinct effects between CuOx and PtCu alloy sites in Pt−Cu bimetallic catalysts for CO oxidation at different temperatures
In situ exploration of the dynamic structure evolution of catalysts plays a key role in revealing reaction mechanisms and designing efficient catalysts. In this work, PtCu/MgO catalysts, synthesized via the co...
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Open AccessSpatial distribution of metabolites in processing Ziziphi Spinosae Semen as revealed by matrix-assisted laser desorption/ionization mass spectrometry imaging
Ziziphi Spinosae Semen (ZSS) is the first choice for the treatment of insomnia. This research aimed to reveal the spatial distribution of identifying quality markers of ZSS and to illustrate the metabolite qualit...
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Open AccessThe value of right ventricular pulmonary artery coupling in determining the prognosis of patients with sepsis
The outcomes of patients with sepsis are influenced by the contractile function of the right ventricle (RV), but the impact of cardiopulmonary interaction in ICU-mortality of sepsis patients remains unclear. T...
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Open AccessKAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2
Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...
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Open AccessBarbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI
Acute myocardial infarction (AMI) has become a public health disease threatening public life safety due to its high mortality. The lateral-flow assay (LFA) of a typical cardiac biomarker, troponin I (cTnI), is...
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Open AccessThree SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective
As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed highly efficacious, intranasal trivalent SARS-CoV-2 vac...
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Open AccessBiparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCS...
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Open AccessMagnetic excitations in strained infinite-layer nickelate PrNiO2 films
Strongly correlated materials respond sensitively to external perturbations such as strain, pressure, and do**. In the recently discovered superconducting infinite-layer nickelates, the superconducting trans...
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Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587
Bedaquiline (BDQ), a first-in-class diarylquinoline anti-tuberculosis drug, and its analogue, TBAJ-587, prevent the growth and proliferation of Mycobacterium tuberculosis by inhibiting ATP synthase1,2. However, B...
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Open AccessNumerical study on the stimulation effect of boundary sealing and hot water injection in marine challenging gas hydrate extraction
This study proposed a novel development mode combining boundary sealing and hot water injection to address the challenges of gas leakage, limited reservoir sensible heat, boundary water intrusion, and low prod...
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Open AccessData-driven prediction on critical mechanical properties of engineered cementitious composites based on machine learning
The present study introduces a novel approach utilizing machine learning techniques to predict the crucial mechanical properties of engineered cementitious composites (ECCs), spanning from typical to exception...
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Open AccessReversible two-way tuning of thermal conductivity in an end-linked star-shaped thermoset
Polymeric thermal switches that can reversibly tune and significantly enhance their thermal conductivities are desirable for diverse applications in electronics, aerospace, automotives, and medicine; however, ...
