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1,643 Result(s)
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Article
Association of the serum levels of saturated fatty acids and mild cognitive impairment: a cross-sectional study
To investigate the association of serum saturated fatty acids (SFAs) and prevalent mild cognitive impairment (MCI) among middle-aged and elderly Chinese.
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Article
Open AccessOvertone photothermal microscopy for high-resolution and high-sensitivity vibrational imaging
Photothermal microscopy is a highly sensitive pump-probe method for map** nanostructures and molecules through the detection of local thermal gradients. While visible photothermal microscopy and mid-infrared...
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Article
Exploring the relationship between institutional legitimacy and teachers’ innovative behavior: the serial mediating effects of psychological empowerment and normative commitment
Teachers play a pivotal role in advancing student learning outcomes and nurturing creativity by continuously innovating their practices. Based on the conservation of resources theory and social exchange theory...
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Open AccessMiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice
Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for incre...
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Nonlinearity optimization for the lattice of SPPC collider ring
The proposed super proton–proton collider (SPPC) is an energy frontier machine that will possess the capability to explore a significantly broader range of new physics models. The nonlinearity optimization of ...
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Article
Ti4+ functionalized zirconium metal-organic frameworks with polymer brushes for specific identification of phosphopeptides in human serum and skimmed milk
In the present study, click chemistry and Schiff base reactions were simultaneously applied to prepare polymer brush (PEG)–functionalized MOF materials (UiO-66-NH2) and immobilized with Ti4+ (MOF-Brush-THBA-Ti4+)...
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Article
Open AccessSpaceflight induces changes in gene expression profiles linked to insulin and estrogen
Organismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans. Here, we extend molecular work to energy metabolism and sex hormone si...
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Article
Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway
Unlike megabats, which rely on well-developed vision, microbats use ultrasonic echolocation to navigate and locate prey. To study ultrasound perception, here we compared the auditory cortices of microbats and ...
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Open AccessIntegration of deep learning and habitat radiomics for predicting the response to immunotherapy in NSCLC patients
The non-invasive biomarkers for predicting immunotherapy response are urgently needed to prevent both premature cessation of treatment and ineffective extension. This study aimed to construct a non-invasive mo...
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Open AccessRisk factors for bloodstream infection among patients admitted to an intensive care unit of a tertiary hospital of Shanghai, China
Blood flow infections (BSIs) is common occurrences in intensive care units (ICUs) and are associated with poor prognosis. The study aims to identify risk factors and assess mortality among BSI patients admitte...
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Open AccessDiffusion-based deep learning method for augmenting ultrastructural imaging and volume electron microscopy
Electron microscopy (EM) revolutionized the way to visualize cellular ultrastructure. Volume EM (vEM) has further broadened its three-dimensional nanoscale imaging capacity. However, intrinsic trade-offs betwe...
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Open AccessEngineering natural microbiomes toward enhanced bioremediation by microbiome modeling
Engineering natural microbiomes for biotechnological applications remains challenging, as metabolic interactions within microbiomes are largely unknown, and practical principles and tools for microbiome engine...
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Article
Potassium isotopic evidence for recycling of surface water into the mantle transition zone
Global water cycling involves interactions between Earth’s interior and its surface environment. Geophysical and mineral physics studies have suggested that the mantle transition zone is hydrous, at least loca...
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Article
Semaglutide attenuates pathological electrophysiological remodeling in diabetic cardiomyopathy via restoring Cx43 expression
Semaglutide is a relatively new anti-hyperglycemic agent that was shown to carry cardioprotective potentials. However, the exact effects of semaglutide on diabetic cardiomyopathy (DCM) and their underlining me...
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Article
Physical insights into non-fullerene organic photovoltaics
Boosted by the fast development of non-fullerene acceptors, organic photovoltaics (OPVs) have achieved breakthrough power conversion efficiencies — in excess of 20% and approaching those of state-of-the-art cr...
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Open AccessA Novel Method to Repair Thin Endometrium and Restore Fertility Based on Menstruation-Derived Stem Cell
Thin endometrium (TE), which mainly occurs as a result of severe damage to the endometrial basalis, is one of the prominent etiologies of menstrual abnormalities, infertility, and recurrent miscarriage in wome...
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Article
Narrow gap welding of 316L thick-section steel with cold metal transition pulsed arc swing
Narrow gap welding of 316L stainless steel thick plate was carried out using the cold metal transition pulsed wire-arc swing method. The effects of heat input, arc swing, and shielding mode on weld sha** and...
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The implications of lipid mobility, drug-enhancers (surfactants)-skin interaction, and TRPV1 activation on licorice flavonoid permeability
Licorice flavonoids (LFs) are derived from perennial herb licorice and have been attaining a considerable interest in cosmetic and skin ailment treatments. However, some LFs compounds exhibited poor permeation...
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Open AccessAssociation between serum vitamin E and bacterial vaginitis in women: a cross-sectional study
Bacterial vaginitis (BV) is a common vaginal disease. Vitamin E has been shown to reduce BV by enhancing immune function, but no studies have analyzed the relationship between vitamin E and BV at different BMI...
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Self-adaptive interval dominance-based feature selection for monotonic classification of interval-valued attributes
Dominance rough set theory is a key mathematical tool for addressing monotonic classification tasks (MCTs). However, current dominance rough set models for feature selection are highly sensitive to noise. Furt...