104 Result(s)
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Open AccessClinical serum lipidomic profiling revealed potential lipid biomarkers for early diabetic retinopathy
Diabetic retinopathy (DR) is a serious complication of diabetes featuring abnormal lipid metabolism. However, the specific lipid molecules associated with onset and progression remain unclear. We used a broad-...
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Open AccessGlobal variability in atmospheric new particle formation mechanisms
A key challenge in aerosol pollution studies and climate change assessment is to understand how atmospheric aerosol particles are initially formed1,2. Although new particle formation (NPF) mechanisms have been de...
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Open AccessInward motion of diamond nanoparticles inside an iron crystal
In the absence of externally applied mechanical loading, it would seem counterintuitive that a solid particle sitting on the surface of another solid could not only sink into the latter, but also continue its ...
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Open AccessThe origin of exceptionally large ductility in molybdenum alloys dispersed with irregular-shaped La2O3 nano-particles
Molybdenum and its alloys are known for their superior strength among body-centered cubic materials. However, their widespread application is hindered by a significant decrease in ductility at lower temperatur...
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Open AccessThe PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation
CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of p...
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Metal telluride nanosheets by scalable solid lithiation and exfoliation
Transition metal tellurides (TMTs) have been ideal materials for exploring exotic properties in condensed-matter physics, chemistry and materials science1–3. Although TMT nanosheets have been produced by top-down...
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Open AccessSupramolecular polynuclear clusters sustained cubic hydrogen bonded frameworks with octahedral cages for reversible photochromism
Develo** supramolecular porous crystalline frameworks with tailor-made architectures from advanced secondary building units (SBUs) remains a pivotal challenge in reticular chemistry. Particularly for hydroge...
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Open AccessPrecise prediction of phase-separation key residues by machine learning
Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact phase separation the most...
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Open AccessChanging of mechanical property and bearing capacity of strongly chlorine saline soil under freeze-thaw cycles
Freeze-thaw cycles and compactness are two critical factors that significantly affect the engineering properties and safety of building foundations, especially in seasonally frozen regions. This paper investig...
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Open AccessRejuvenation as the origin of planar defects in the CrCoNi medium entropy alloy
High or medium- entropy alloys (HEAs/MEAs) are multi-principal element alloys with equal atomic elemental composition, some of which have shown record-breaking mechanical performance. However, the link between...
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Open AccessRescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by sha** osteocyte calcium dynamics
Type 2 diabetes (T2D)-related fragility fractures represent an increasingly tough medical challenge, and the current treatment options are limited. Mechanical loading is essential for maintaining bone integrit...
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Open AccessSelenium-based metabolic oligosaccharide engineering strategy for quantitative glycan detection
Metabolic oligosaccharide engineering (MOE) is a classical chemical approach to perturb, profile and perceive glycans in physiological systems, but probes upon bioorthogonal reaction require accessibility and ...
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Three-dimensional atomic structure and local chemical order of medium- and high-entropy nanoalloys
Medium- and high-entropy alloys (M/HEAs) mix several principal elements with near-equiatomic composition and represent a model-shift strategy for designing previously unknown materials in metallurgy1–8, catalysis
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Open AccessResearch on point cloud hole filling and 3D reconstruction in reflective area
3D reconstruction is the process of obtaining the three-dimensional shape or surface structure of an object, which is widely used in advanced manufacturing fields such as automotive, aerospace, industrial insp...
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Open AccessmRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge
The recent outbreaks of mpox have raised concerns over the need for effective vaccines. However, the current approved vaccines have either been associated with safety concerns or are in limited supply. mRNA va...
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Open AccessChemical inhomogeneity–induced profuse nanotwinning and phase transformation in AuCu nanowires
Nanosized metals usually exhibit ultrahigh strength but suffer from low homogeneous plasticity. The origin of a strength–ductility trade-off has been well studied for pure metals, but not for random solid solu...
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Open AccessDirectly imaging excited state-resolved transient structures of water induced by valence and inner-shell ionisation
Real-time imaging of transient structure of the electronic excited state is fundamentally critical to understand and control ultrafast molecular dynamics. The ejection of electrons from the inner-shell and val...
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Open AccessH2 formation via non-Born-Oppenheimer hydrogen migration in photoionized ethane
Neutral H2 formation via intramolecular hydrogen migration in hydrocarbon molecules plays a vital role in many chemical and biological processes. Here, employing cold target recoil ion momentum spectroscopy (COLT...
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Open AccessMechanical behavior and reloading reinforcement characteristics of fractured coal under low confining pressure
To study the basic mechanical behavior and the reloading reinforcement characteristics of fractured coal, conventional triaxial loading tests with different fissure angle were first carried out. On this basis,...
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Open AccessNO at low concentration can enhance the formation of highly oxygenated biogenic molecules in the atmosphere
The interaction between nitrogen monoxide (NO) and organic peroxy radicals (RO2) greatly impacts the formation of highly oxygenated organic molecules (HOM), the key precursors of secondary organic aerosols. It ha...
