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Article
Modeling and experimental study of surface generation in ultrasonic vibration-assisted grinding of Ti-6Al-4V micro-channels
The precision machining of Ti-6Al-4V (TC4) micro-channels remains a challenge due to the poor surface integrity and limited tool life. Ultrasonic vibration-assisted grinding (UVAG) is a promising technique tha...
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Article
Open AccessPeNAC67-PeKAN2-PeSCL23 and B-class MADS-box transcription factors synergistically regulate the specialization process from petal to lip in Phalaenopsis equestris
The molecular basis of orchid flower development involves a specific regulatory program in which MADS-box transcription factors play a central role. The recent ‘perianth code’ model hypothesizes that two types...
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Article
Comparative analysis of the economic feasibility of Tiger puffer (Takifugu rubripes) aquaculture in China
Tiger puffer (Takifugu rubripes) is one of the most expensive farmed marine fish species in China. The high profitability of farmed tiger puffer is used to attract many new investors. However, some investments...
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Article
Open AccessDynamic multi-strategy integrated differential evolution algorithm based on reinforcement learning for optimization problems
The introduction of a multi-population structure in differential evolution (DE) algorithm has been proven to be an effective way to achieve algorithm adaptation and multi-strategy integration. However, in exis...
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Article
Open AccessOptimus: association-based dynamic system call filtering for container attack surface reduction
While container adoption has witnessed significant growth in facilitating the operation of large-scale applications, this increased attention has also attracted adversaries who exploit numerous vulnerabilities...
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Article
Conditional Denoising Diffusion Implicit Model for Speech Enhancement
Recently, denoising diffusion probabilistic models (DDPMs) have been effective in speech enhancement. However, existing models largely follow the original diffusion training method, ignoring the trade-off betw...
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Article
Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets
The nuclear factor κappa B (NF-κB) signaling plays a well-known function in inflammation and regulates a wide variety of biological processes. Low-grade chronic inflammation is gradually considered to be close...
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Article
PocketFlow is a data-and-knowledge-driven structure-based molecular generative model
Deep learning-based molecular generation has extensive applications in many fields, particularly drug discovery. However, the majority of current deep generative models are ligand-based and do not consider che...
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Article
Open AccessModel construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection
Clinically, hormone replacement therapy (HRT) is the main treatment for primary ovarian insufficiency (POI). However, HRT may increase the risk of both breast cancer and cardiovascular disease. Exosomes derive...
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Article
Boundedness of Operators on Weighted Morrey–Campanato Spaces in the Bessel Setting
Let \(\lambda \in (-\frac{1}{2},\infty )\) λ ∈ ...
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Article
Ligand recognition and G-protein coupling of trace amine receptor TAAR1
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have essential roles in neurological and metabolic homeostasis1. They recognize diverse endogenous trace amines and subsequently acti...
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Article
Open AccessRepression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer (OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1/2 and other DNA repair pathway mem...
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Article
5G Edge Intelligence-based Refined Power Distribution Monitoring Technology and Application
The operating environment of electric meter boxes is very complex and contains various emergencies such as power theft and fire. When emergency occurs, it is urgent to dispatch correlated sensors to collect an...
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Article
Silencing ApoC3 alleviates LPS-induced acute lung injury by inhibiting TLR signaling pathway
This study aims to confirm whether apolipoprotein C3 (ApoC3) can regulate the inflammatory response and tissue damage in acute lung injury (ALI) and explore its regulatory pathway. ALI mouse model was establis...
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Article
Matrix Weighted Kolmogorov–Riesz’s Compactness Theorem
In this paper, several versions of the Kolmogorov–Riesz compactness theorem in weighted Lebesgue spaces with matrix weights are obtained. In particular, when the matrix weight W is in the known Ap class, a charac...
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Article
Influence of asymmetric tidal mixing on sediment dynamics in a partially mixed estuary
To investigate the influence of asymmetric tidal mixing (ATM) on sediment dynamics in tidal estuaries, we developed a vertically one-dimensional idealized analytical model, in which the M2 tidal flow, residual fl...
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Article
Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution
Host–pathogen interactions and pathogen evolution are underpinned by protein–protein interactions between viral and host proteins. An understanding of how viral variants affect protein–protein binding is impor...
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Article
Open AccessDeciphering a cell death-associated signature for predicting prognosis and response to immunotherapy in lung squamous cell carcinoma
Lung squamous cell carcinoma (LUSC) is a subtype of non-small cell carcinoma, accounting for about 30% of all lung cancers. Yet, the evaluation of prognostic outcome and therapy response of patients with LUSC ...
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Article
A new vanishing Lipschitz-type subspace of BMO and compactness of bilinear commutators
A new vanishing Lipschitz-type space called \({\mathrm {XMO}}_\alpha \,(\mathbb {R}^n)\) ...
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Article
Open AccessComparison of the different animal modeling and therapy methods of premature ovarian failure in animal model
Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very complex, which is closely related to genes, immune diseases, drugs, surgery, and psycho...
