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Article
Stable inhibition of choroidal neovascularization by adeno-associated virus 2/8-vectored bispecific molecules
Neovascular age-related macular degeneration (nAMD) causes severe visual impairment. Pigment epithelium-derived factor (PEDF), soluble CD59 (sCD59), and soluble fms-like tyrosine kinase-1 (sFLT-1) are potentia...
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Article
Large Active Faults and the Wharton Basin Intraplate Earthquakes in the Eastern Indian Ocean
In recent years, great earthquakes occurred within the Wharton Basin in the eastern Indian Ocean, and they have been associated with active faulting on the ancient oceanic crust. Large seismogenic faults were ...
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Article
Crustal Structure of the Jurassic Quiet Zone in the West Pacific Ocean: Insights from 2D Multichannel Seismic Reflection Profiles
The Jurassic oceanic crust is the oldest existing oceanic crust on earth, and although distributed sparsely, carries essential information about the earth’s evolution. The area around the Pigafetta Basin in th...
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Article
Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose
Neurodegenerative diseases and postoperative cognitive dysfunction involve the accumulation of β-amyloid peptide (Aβ). High glucose can inhibit autophagy, which facilitates intracellular Aβ clearance. The α2-a...
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Article
Bariatric surgery normalizes diabetes risk index by one month post-operation
The Diabetes risk index (DRI) is a composite of NMR-measured lipoproteins and branched chain amino acids predictive of diabetes mellitus development. Bariatric surgery is indicated in patients with severe obes...
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Article
The impact of marine tourism behavior on the ecological effect of marine benthos Community in the South China Sea
In the face of the complexity and variability of the marine environment, the coastal water quality is seriously polluted by the marine tourism behavior, and the ecosystem structure is degraded, which restricts...
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Article
Open AccessGenomic profiling of a patient with quadruple synchronous colorectal cancer: a case report
Synchronous colorectal cancer (SCRC) is featured by the presence of multiple primary tumor lesions in a single patient at initial diagnosis. It is less common with the prevalence of approximately 3.5% among co...
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Article
Open AccessStudy on the optimal design of volume fracturing for shale gas based on evaluating the fracturing effect—A case study on the Zhao Tong shale gas demonstration zone in Sichuan, China
Hydraulic fracturing is the key technology in the development of shale gas reservoirs, and it mainly adopts volume fracturing technology to communicate hydraulic fractures with natural fractures to increase th...
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Article
Amitriptyline Protects Against Lidocaine-induced Neurotoxicity in SH-SY5Y Cells via Inhibition of BDNF-mediated Autophagy
Amitriptyline (AMI) is a traditional tricyclic antidepressant that has been proven to exhibit neuroprotective effects in various neurological disorders. However, the underlying mechanism by which AMI attenuate...
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Article
Open AccessImproving the blast resistance of the elite rice variety Kongyu-131 by updating the pi21 locus
As an elite japonica rice variety, Kongyu-131 has been cultivated for over 20 years in the third accumulated temperature zone of Heilongjiang Province, China. However, the cultivated area of Kongyu-131 has decrea...
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Article
Open AccessCD317 Promotes the survival of cancer cells through apoptosis-inducing factor
Low nutrient environment is a major obstacle to solid tumor growth. However, many tumors have developed adaptive mechanisms to circumvent the requirement for exogenous growth factors.
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Chapter and Conference Paper
Optimizing the Individual Differences of EEG Signals through BP Neural Network Algorithm for a BCI Dialing System
Brain-computer interface (BCI) establishes an additional pathway between brain and the external environment. With BCIs, paraplegic patients or the elderly people can communicate with others conveniently and fi...
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Article
Synthesis of Nucleoside N-Phosphoamino Acids and Peptide Formation
Nucleoside N-phosphoamino acids were synthesized through Atherton-Todd reaction of nucleoside H-phosphonate with amino acids, and their structures were confirmed by NMR and ESI-MS. After nucleoside N-phosphoamino...
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Article
Penta-coordinate phosphorous compounds and biochemistry
The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to...
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Article
Building of the petroleum drilling fluid engineering design expert system
The targets, importance, difficulties, strategies, general function frame and technology frame of Petroleum Drilling Fluid Engineering Design Expert Ssytem(PDFEDES) were discussed. A brief introduction to the ...
