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Penta-coordinate phosphorous compounds and biochemistry

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Abstract

The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipeptide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

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Authors and Affiliations

  1. Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, 100084, Bei**g, China

    Changxue Lin, Yanmei Li, Changmei Cheng, Bo Han, Rong Wan & Yufen Zhao

  2. Department of Chemistry, **amen University, 361005, **amen, China

    Yabing Feng & Yufen Zhao

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  1. Changxue Lin
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  2. Yanmei Li
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  3. Changmei Cheng
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  4. Bo Han
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  5. Rong Wan
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  7. Yufen Zhao
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Correspondence to Yufen Zhao.

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Lin, C., Li, Y., Cheng, C. et al. Penta-coordinate phosphorous compounds and biochemistry. Sc. China Ser. B-Chem. 45, 337–348 (2002). https://doi.org/10.1007/BF02879344

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  • DOI: https://doi.org/10.1007/BF02879344

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