24 Result(s)
within
**guang Gu
Biomedicine
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Article
The neuronal and synaptic dynamics underlying post-inhibitory rebound burst related to major depressive disorder in the lateral habenula neuron model
A burst behavior observed in the lateral habenula (LHb) neuron related to major depressive disorder has attracted much attention. The burst is induced from silence by the excitatory N-methyl-D-aspartate (NMDA) sy...
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Article
Dynamics of interaction between IH and IKLT currents to mediate double resonances of medial superior olive neurons related to sound localization
Neurons in the medial superior olive (MSO) exhibit high frequency responses such as subthreshold resonance, which is helpful to sensitively detect a small difference in the arrival time of sounds between two e...
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Article
The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions
Conduction delay and failure behaviors of action potentials with a high frequency along nerve fiber are related to the abnormal functions. For instance, upregulation of a hyperpolarization-activated cation cur...
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Article
Influence of inhibitory autapses on synchronization of inhibitory network gamma oscillations
A recent experimental study showed that inhibitory autapses favor firing synchronization of parvalbumin interneurons in the neocortex during gamma oscillations. In the present paper, to provide a comprehensive...
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Article
Nonlinear mechanism for the enhanced bursting activities induced by fast inhibitory autapse and reduced activities by fast excitatory autapse
The paradoxical phenomena that excitatory modulation does not enhance but reduces or inhibitory modulation not suppresses but promotes neural firing activities have attracted increasing attention. In the prese...
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Article
Complex dynamics of hair bundle of auditory nervous system (II): forced oscillations related to two cases of steady state
The forced oscillations of hair bundle of inner hair cells of auditory nervous system evoked by external force from steady state are related to the fast adaption of hair cells, which are very important for aud...
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Article
Complex dynamics of hair bundle of auditory nervous system (I): spontaneous oscillations and two cases of steady states
The hair bundles of inner hair cells in the auditory nervous exhibit spontaneous oscillations, which is the prerequisite for an important auditory function to enhance the sensitivity of inner ear to weak sound...
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Article
Open AccessRecognize the role of CD146/MCAM in the osteosarcoma progression: an in vitro study
Osteosarcoma (OS) is a common malignant bone tumor with poor prognosis. We previously reviewed that CD146 is correlated with multiple cancer progression, while its impact on OS is currently not systematically ...
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Article
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection
In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise memory-like and terminally exhausted subsets. However, little is known about the molecular profile and fate of these two ...
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Article
Coherence resonance for neuronal bursting with spike undershoot
Although the bursting patterns with spike undershoot are involved with the achievement of physiological or cognitive functions of brain with synaptic noise, noise induced-coherence resonance (CR) from resting ...
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Article
Open AccessPrevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis
Cytomegalovirus infection is one of the most common complications after solid organ transplantation. There have been several classes of antiviral drugs for the prevention of cytomegalovirus infection, such as ...
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Article
Open Access6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression
Anti-angiogenic therapies demonstrate anti-tumor effects by decreasing blood supply to tumors and inhibiting tumor growth. However, anti-angiogenic therapy may leads to changes in tumor microenvironment and in...
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Article
Open AccessImpact of cancer mutational signatures on transcription factor motifs in the human genome
Somatic mutations in cancer genomes occur through a variety of molecular mechanisms, which contribute to different mutational patterns. To summarize these, mutational signatures have been defined using a large...
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Article
A basic bifurcation structure from bursting to spiking of injured nerve fibers in a two-dimensional parameter space
Two different bifurcation scenarios of firing patterns with decreasing extracellular calcium concentrations were observed in identical sciatic nerve fibers of a chronic constriction injury (CCI) model when the...
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Article
Open AccessA phase I study of nedaplatin, pemetrexed and thoracic intensity-modulated radiotherapy for inoperable stage III lung adenocarcinoma
Concurrent chemotherapy and radiation is the standard treatment for unresectable stage III Lung adenocarcinoma. However, no optimal concurrent chemotherapeutic regimen has been described. This study aimed to a...
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Chapter and Conference Paper
Phase Noise-Induced Transition from Single Coherence Resonance to Double Coherence Resonances in a Neuronal Model
We study the influence of phase noise on the coherence dynamics of the FitzHugh–Nagumo (FHN) model. By analyzing the coefficient variations (CV) of interspike interval (ISI) series for different noise intensit...
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Chapter and Conference Paper
Transition Between Synchronous Behaviors of Coupled Neurons with Reciprocal Inhibition and Time Delay
Synchronization of two coupled bursting neurons with reciprocal inhibition and time delay is studied. When coupling strength is small, a single synchronous firing pattern appears at a time delay less than the ...
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Article
BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence
Guido Sauter, Roland Eils, Christoph Plass, Raffaella Santoro and colleagues report that the gene encoding the epigenetic regulator BAZ2A is overexpressed in prostate cancer, where it interacts with EZH2 to in...
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Article
Identifying type I excitability using dynamics of stochastic neural firing patterns
The stochastic firing patterns are simulated near saddle-node bifurcation on an invariant cycle corresponding to type I excitability in stochastic Morris–Lecar model. In absence of external periodic signal, th...
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Article
Dynamics of period-doubling bifurcation to chaos in the spontaneous neural firing patterns
Period-doubling bifurcation to chaos were discovered in spontaneous firings of Onchidium pacemaker neurons. In this paper, we provide three cases of bifurcation processes related to period-doubling bifurcation...
