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Article
Open AccessLysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE
Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)....
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Article
Review on role of electrical discharge drilling methods in fabricating micro holes: formation mechanism, defects characterization and mitigation strategies
Electrical discharge drilling (EDD), a non-contact manufacturing technology that brings the potential to fabricate microholes at low cost and relatively high efficiency, has aroused extensive attention at home...
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Article
Effects of supplementary astaxanthin in egg custard on antioxidant capacity and non-specific immunity during larvae metamorphosis of giant freshwater prawn (Macrobrachium rosenbergii)
The effects of different astaxanthin levels on antioxidant capacity and non-specific immunity in phase V~X larvae of giant freshwater prawn, Macrobrachium rosenbergii, were investigated; furthermore, the differen...
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Article
LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling
This study thoroughly investigated the role of the long non-coding RNA LOXL1-AS1 in the pathogenesis of cholangiocarcinoma (CCA). Through bioinformatics analysis and tissue samples validation, the study found ...
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Article
Open AccessAgricultural land management and rural financial development: coupling and coordinated relationship and temporal-spatial disparities in China
The integrated development of agricultural land and finance not only promotes rural financial innovation and breaks the bottleneck of agricultural financing but also facilitates agricultural land transfer and ...
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Article
Open AccessEfficacy of acupuncture as an adjunctive treatment to patients with stable COPD: a multicenter, randomized, sham-controlled trial protocol
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease and the third leading cause of death worldwide. Previous evidence has shown that acupuncture may be an effective complementary alter...
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Article
Open AccessRapid synthesis of phosphor-glass composites in seconds based on particle self-stabilization
Phosphor-glass composites (PGC) are excellent candidates for highly efficient and stable photonic converters; however, their synthesis generally requires harsh procedures and long time, resulting in additional...
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Chapter and Conference Paper
Atomistic Simulation of Hydrogen-Defect Interactions in Palladium Nanoparticles Across Multiple Time Scales
This paper aims to explore solute-defect interactions in nanosized palladium-hydrogen (Pd-H) systems across multiple time scales through two atomistic methods. The first method, namely Diffusive Molecular (D...
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Article
Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane
Repeated neonatal exposure to anesthetics may disturb neurodevelopment and cause neuropsychological disorders. The m6A modification participates in the gene regulation of neurodevelopment in mouse fetuses expo...
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Article
Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation
DNA methylation (DNAm) is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes. The variation of DNAm in the human population is related to both genetic and environme...
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Article
Open AccessThe NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway
Immunosuppressive cells play important roles in generating an immunosuppressive tumor microenvironment and facilitating tumor immune escape. However, the molecular mechanisms underlying their immunosuppressive...
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Article
Long-Term Storage Capability Prediction for Composite Directors in MLRS: Considering the Influence of Actual Environment
To predict the long-term storage capability (LTSC) of composite directors for multiple launch rocket system (MLRS) in the actual environment, a creep constitutive model was established in a three-dimensional n...
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Article
Open AccessIdentification of immune infiltration-related biomarkers in carotid atherosclerotic plaques
Atherosclerosis is a chronic lipid-driven inflammatory response of the innate and adaptive immune systems, and it is responsible for several cardiovascular ischemic events. The present study aimed to determine...
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Article
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
Previous studies have revealed that patients with hypertrophic cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating potential HCM subtypes among these patients. Here, 793 pati...
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Article
Decarbonization kinetics for fluidized roasting of vanadium-bearing carbonaceous shale
Nonisothermal and isothermal kinetic studies were carried out to determine the decarbonization mechanism for fluidized roasting of vanadium-bearing carbonaceous shale. The nonisothermal kinetics were calculate...
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Article
Open AccessIn-plane hyperbolic polariton tuners in terahertz and long-wave infrared regimes
One of the main bottlenecks in the development of terahertz (THz) and long-wave infrared (LWIR) technologies is the limited intrinsic response of traditional materials. Hyperbolic phonon polaritons (HPhPs) of ...
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Article
Reaction behavior and non-isothermal kinetics of suspension magnetization roasting of limonite and siderite
In order to develop limonite and decrease CO2 emissions, siderite is proposed as a clean reductant for suspension magnetization roasting (SMR) of limonite. An iron concentrate (iron grade: 65.92wt%, iron recovery...
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Article
Thermal and Electrical Conductivities of Platinum/Iridium Microwires
The thermal and electrical conductivities of individual platinum-iridium (Pt-Ir) wires with a diameter of about 80 μm in different compositions are measured in the temperature range from 100 K to 300 K. Exper...
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Article
Analysis of thermal and wet stress of corn kernel based on microwave drying
In order to reveal the relationship between temperature, moisture content and stress during microwave drying, the paper establishes a mathematical model of heat and mass transfer as well as stress during micro...
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Article
Open AccessAcyl carrier protein tag can enhance tobacco etch virus protease stability and promote its covalent immobilisation
Fusion expression is widely employed to enhance the solubility of recombinant proteins. However, removal of the fusion tag is often required due to its potential impact on the structure and activity of passeng...
