15 Result(s)
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Article
Open AccessGenome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by disseminati...
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Open AccessTumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subty** strategy and immunotherapeutic prediction model
Molecular subty** is expected to enable precise treatment. However, reliable subty** strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunct...
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Open AccessKnockdown of NCAPD3 inhibits the tumorigenesis of non-small cell lung cancer by regulation of the PI3K/Akt pathway
Accumulating evidence indicates that aberrant non-SMC condensin II complex subunit D3 (NCAPD3) is associated with carcinogenesis of various cancers. Nevertheless, the biological role of NCAPD3 in the pathogene...
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Open AccessGenomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma
Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to syste...
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Open AccessCACA guidelines for holistic integrative management of esophageal carcinoma
Esophageal carcinoma (EC) is a common malignant tumor of the upper digestive tract worldwide. An analysis of the latest data from cancer centers in China showed that the incidence of EC and the number of death...
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Open AccessComprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics
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Open AccessApatinib plus etoposide in pretreated patients with advanced triple-negative breast cancer: a phase II trial
Treatment options for pretreated triple-negative breast cancer (TNBC) are limited. This study aimed to evaluate the efficacy and safety of apatinib, an antiangiogenic agent, in combination of etoposide for pre...
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Open AccessEfficacy and safety of Elian Granules in treating chronic atrophic gastritis: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial
Multifocal atrophic gastritis and intestinal metaplasia are considered to be important links in the gastric precancerous cascade. However, there are no specific drugs for these conditions. Although many studie...
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Open AccessA comparison of the clinical effects of thinning and drilling on laser-assisted hatching
To systematically investigate the effects of two methods used for laser-assisted hatching (LAH) on clinical outcomes after day 4 (D4) on frozen-embryo-transfer (FET) cycles. Data from 11471 infertile patients ...
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Open AccessEffect of acupuncture at Zusanli (ST36) point on antral contraction function under ultrasound guidance: study protocol of a randomized controlled trial
Although the relationship between deqi sensations and curative effect has always been controversial, deqi sensations has been regarded as the key indicator of clinical efficacy of acupuncture therapy. There is li...
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Open AccessA global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
Multimorbidities greatly increase the global health burdens, but the landscapes of their genetic risks have not been systematically investigated.
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Article
Open AccessCombined effect of hypertension and hyperuricemia on ischemic stroke in a rural Chinese population
To investigate the combined effect of hypertension and hyperuricemia to the risk of ischemic stroke in a rural Chinese population.
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Article
Open AccessEfficacy of chloroquine versus lopinavir/ritonavir in mild/general COVID-19 infection: a prospective, open-label, multicenter, randomized controlled clinical study
The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. The adage “old drug, new trick” in this context may suggest the important therapeut...
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Open AccessPrevalence and factors associated with occupational burnout among HIV/AIDS healthcare workers in China: a cross-sectional study
Burnout is a psychosomatic syndrome characterized by three dimensions (emotional exhaustion [EE], feelings of depersonalization [DP], and reduced personal accomplishment [PA]). We determined the prevalence of ...
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Article
Open AccessHypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts
Microtubule-associated protein tau (MAPT) is abundant in neurons and functions in assembly and stabilization of microtubules to maintain cytoskeletal structure. Human MAPT transcripts undergo alternative splicing...
