-
Article
Open AccessSemantic segmentation of point clouds of ancient buildings based on weak supervision
Semantic segmentation of point clouds of ancient buildings plays an important role in Historical Building Information Modelling (HBIM). As the annotation task of point cloud of ancient architecture is characte...
-
Article
Photonics joint radar and communication system using dual-band LFM-based signals with opposite chirp polarities
A photonics joint radar and communication (JRC) system using dual-band linear frequency modulation (LFM)-based waveforms is proposed and demonstrated. In the scheme, four optical chirp sidebands are generated ...
-
Article
Efficacy and safety of a combination treatment of immune checkpoint inhibitors in metastatic breast cancer: a systematic review and meta-analysis
Immune checkpoint inhibitors (ICIs) in combination with chemotherapy have showed its benefits in clinical studies, and here we conducted a further evaluation on the safety and efficacy of this treatment strategy.
-
Article
Open AccessGuiding antibiotics towards their target using bacteriophage proteins
Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster and cheaper way to get them might be by repurposing existing antibiotics. Nanodelivery system...
-
Article
Correction: Smoking Impacts Alzheimer’s Disease Progression Through Oral Microbiota Modulation
-
Article
Smoking Impacts Alzheimer’s Disease Progression Through Oral Microbiota Modulation
Alzheimer’s disease (AD) is an important public health challenge with a limited understanding of its pathogenesis. Smoking is a significant modifiable risk factor for AD progression, and its specific mechanism...
-
Article
Revitalization and propagation approach of Chinese historical dictionaries in the digital age
Chinese dictionary publishing has a long history, and the innovation of publishing technology in the age of digital intelligence has enabled the activation of historical dictionaries. The current situation of ...
-
Article
Hemodynamics in nutcracker syndrome: implications for diagnosis
Nutcracker syndrome is a disease characterized by complex symptoms, making its diagnosis challenging and often delayed, often resulting in a painful experience for the patients.
-
Article
Open AccessHigh frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats
Drug addiction represents a multifaceted and recurrent brain disorder that possesses the capability to create persistent and ineradicable pathological memory. Deep brain stimulation (DBS) has shown a therapeut...
-
Article
Open AccessCordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC).
-
Article
Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a broad spectrum of symptoms and prognoses. Effective therapy requires understanding this variability. ASD children’s cognitive an...
-
Article
High-linearity graphene-based temperature sensor fabricated by laser writing
In this work, the preparation of high-linearity flexible graphene-based temperature sensors by laser writing directly on polyimide (PI) substrates was proposed. The combined effects of the power density of the...
-
Article
Open AccessPrognostic and risk factor analysis of cancer patients after unplanned ICU admission: a real-world multicenter study
To investigate the occurrence and 90-day mortality of cancer patients following unplanned admission to the intensive care unit (ICU), as well as to develop a risk prediction model for their 90-day prognosis. W...
-
Article
Open AccessImmune checkpoint inhibitors for multiple myeloma immunotherapy
Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit MM patients. Immune checkpoints can negatively modulate the immune system and are closel...
-
Article
Open AccessProenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration
Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the mechanisms underlying this intricate molecular crosstalk remain elusive. In this study, t...
-
Article
Efficacy and safety of novel biologics in the treatment of lupus nephritis based on registered clinical trials: a systematic review and network meta-analysis
To compare the clinical effectiveness and safety of novel biologics for the treatment of lupus nephritis based on a reticulated meta-analysis approach. Registered clinical trials in 4 major databases (PubMed, ...
-
Article
The clinical value of monoclonal protein in ANCA-associated vasculitis with renal involvement
The value of monoclonal protein (M-protein) in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients with renal involvement has not been investigated.
-
Article
Efficient photodegradation of 2, 4-D by B-doped g-C3N4 nanosheets prepared by a two-step thermal polymerization method
The photocatalytic application of graphic carbon nitrate (g-C3N4) was limited due to the defects of few exposed active sites and serious recombination rate of photogenerated carrier. In this paper, boric acid-ass...
-
Article
Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment
Although DNA mutation drives stem cell aging, how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly understood. Here, using a mouse model of irradiation-induced premature agin...
-
Article
Open AccessIf we should remove internal fixation devices for rib fractures?
Internal fixation for rib fractures has been widely carried out worldwide, and its surgical efficacy has been recognized. However, there is still controversy about whether implant materials need to be removed....
