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Article
Open AccessNoncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions
Calcific aortic valve disease (CAVD) is becoming an increasingly important global medical problem, but effective pharmacological treatments are lacking. Noncoding RNAs play a pivotal role in the progression of...
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Article
Open AccessAdvanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced gl...
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Article
Pioneering the Way: The Revolutionary Potential of Antibody–Drug Conjugates in NSCLC
Despite targeted therapy and immunotherapy being recognized as established frontline treatments for advanced non-small cell lung cancer (NSCLC), the unavoidable development of resistance and disease progressio...
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Article
Cellulose acetate-based composite fibrous membrane with asymmetric wettability for directional water transport and high-flux oil–water separation
The investigation of dual-layer fibrous membranes with asymmetric wettability is gaining growing interest. Here, we conceive a novel composite fibrous membrane base on cellulose acetate (CA), characterized by ...
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Article
Model Construction of Nonwovens with Hierarchically-Structured Fiber Morphology
Nonwoven microstructural geometries strongly influence the performance of nonwovens in practical application. Designing nonwovens for the specific environment of the targeted application will have to rely on t...
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Article
Open Accessα-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice
In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity and aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated my...
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Article
Open AccessCD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SAE). Microglia-mediated inflammatory signaling is involved in anxiety, depression, and c...
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Article
Open AccessJ147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway
Neuroinflammation is associated with the pathophysiology of depression. The molecular mechanism of depressive-like behavior caused by sepsis-associated encephalopathy (SAE) is incompletely understood. J147 (an...
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Article
Combining Radiotherapy with Immunotherapy in Cervical Cancer: Where Do We Stand and Where Are We Going?
Combining immunotherapy and radiotherapy as a treatment strategy for cervical cancer has attracted increasing attention. The primary objective of this review is to provide an up-to-date summary of the knowledg...
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Open AccessCurrent evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
Curcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is ...
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Article
Open AccessTargeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice
Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced o...
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Article
Efficient, Breathable and Biodegradable Filter Media for Face Masks
The global outbreak of COVID-19 results in the surge of disposable sanitary supplies, especially personal protective face masks. However, the charge dissipation of the electret meltblown nonwovens, which predo...
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Article
Open AccessPhase separation in cancer at a glance
Eukaryotic cells are segmented into multiple compartments or organelles within the cell that regulate distinct chemical and biological processes. Membrane-less organelles are membrane-less microscopic cellular...
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Article
Open AccessAssociation between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey
Recent studies have found that polycyclic aromatic hydrocarbons (PAHs) exposure may increase the risk of cardiovascular disease. The present study aimed to explore the association between PAHs exposure and sev...
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Article
Open AccessAsymptotic Simplification of Aggregation-Diffusion Equations Towards the Heat kernel
We give sharp conditions for the large time asymptotic simplification of aggregation-diffusion equations with linear diffusion. As soon as the interaction potential is bounded and its first and second derivati...
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Article
Neuropsychological Interventions for Cancer-Related Cognitive Impairment: A Network Meta-Analysis of Randomized Controlled Trials
The aim of this network meta-analysis was to evaluate the comparative effects of neuropsychological interventions for cancer-related cognitive impairment (CRCI), and to rank the best intervention options for a...
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Article
Multi-layered micro/nanofibrous nonwovens for functional face mask filter
The worldwide COVID-19 pandemic has led to an attention on the usage of personal protective face masks. However, the longevity and safety of the commercial face masks are limited due to the charge dissipation ...
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Article
Open AccessConceptualizing problems with symptoms, function, health behavior, health-seeking skills, and financial strain in breast cancer survivors using hierarchical clustering
Determine whether a diverse set of problems experienced by breast cancer survivors (BCS) following curative treatment can be formulated into a reduced number of clusters, potentially simplifying the conceptual...
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Article
Monocytes augment inflammatory responses in human aortic valve interstitial cells via β2-integrin/ICAM-1-mediated signaling
Inflammatory infiltration in aortic valves promotes calcific aortic valve disease (CAVD) progression. While soluble extracellular matrix (ECM) proteins induce inflammatory responses in aortic valve interstitia...
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Article
Open AccessSalt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury
Receptor-interacting protein kinase 3 (RIPK3) functions as a central regulator of necroptosis, mediating signaling transduction to activate pseudokinase mixed lineage kinase domain-like protein (MLKL) phosphor...
