15 Result(s)

Article

Transient in uteroknockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse

Developmentally important genes often result in early lethality in knockout animals. Thus, the direct role of genes in late gestation organogenesis cannot be assessed directly. In utero delivery of transgenes was...

J Craig Cohen, Donald K Scott, James Miller, Jianxuan Zhang… in BMC Developmental Biology (2004)

Article

Maximizing target protein ablation by integration of RNAi and protein knockout

Jeffrey Hannah, Pengbo Zhou in Cell Research (2011)

Article

Transcription analysis on response of swine lung to H1N1 swine influenza virus

As a mild, highly contagious, respiratory disease, swine influenza always damages the innate immune systems, and increases susceptibility to secondary infections which results in considerable morbidity and mor...

Yongtao Li, Hongbo Zhou, Zhibin Wen, Shujuan Wu, Canhui Huang, Guangmin Jia… in BMC Genomics (2011)

Article

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis

Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not under...

Liren Liu, Yan Yin, Yuewei Li, Lisa Prevedel, Elizabeth H Lacy, Liang Ma… in Cell Research (2012)

Article

CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2

NS2 from influenza A virus mediates Crm1-dependent vRNP nuclear export through interaction with Crm1. However, even though the nuclear export signal 1 (NES1) of NS2 does not play a requisite role in NS2–Crm1 i...

Yong Hu, **aokun Liu, Anding Zhang, Hongbo Zhou… in Cellular and Molecular Life Sciences (2015)

Article

Characterization of enzymatic properties of two novel enzymes, 3,4-dihydroxyphenylacetate dioxygenase and 4-hydroxyphenylacetate 3-hydroxylase, from Sulfobacillus acidophilus TPY

As an environmental pollutant, 4-hydroxyphenylacetate (4-HPA) was a product of softwood lignin decomposition and was found in industrial effluents from olive oil production. Sulfobacillus acidophilus TPY was a mo...

Wenbin Guo, Wengen Zhou, Hongbo Zhou, **nhua Chen in BMC Microbiology (2019)

Article

Deciphering microbial diversity associated with Fusarium wilt-diseased and disease-free banana rhizosphere soil

Fusarium wilt of banana (Musa spp.) caused by the fungal pathogen Fusarium oxysporum f. sp. cubense (Foc) is a typical soilborne disease, that severely devastates the banana industry worldwide, and soil microbial...

Dengbo Zhou, Tao **g, Yufeng Chen, Fei Wang, Dengfeng Qi, Renjun Feng… in BMC Microbiology (2019)

Article

Activating PIK3CA mutation promotes osteogenesis of bone marrow mesenchymal stem cells in macrodactyly

Macrodactyly is a disabling congenital disease characterized by overgrowth of soft tissues and bones, which leads to finger enlargement and joint deformity. The mechanism of bone overgrowth in macrodactyly was...

Hengqing Cui, Gang Han, Bin Sun, **a Fang, **nyi Dai, Shengbo Zhou… in Cell Death & Disease (2020)

Article

Activating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1

Macrodactyly is a congenital malformation characterized by enlargement of bone and soft tissues in limbs, typically with excessive accumulation of adipose tissues. Although gain-of-function mutation of PIK3CA ...

Bin Sun, Yongkang Jiang, Hengqing Cui, **a Fang, Gang Han… in Cell Death & Disease (2020)

Article

UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer

UBR5, a HECT-domain E3 ubiquitin ligase, is an attractive therapeutic target for aggressive breast cancers. Defining the substrates of UBR5 is crucial for scientific understanding and clinical intervention. He...

Gang **ang, Shuxuan Wang, Ling Chen, Mei Song, **aoxu Song… in Cell Death & Disease (2022)

Article

COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...

Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu… in Cell Discovery (2022)

Article

The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy among primary liver cancers, with an increasing overall incidence and poor prognosis. The intertumoral and intratumoral heterogeneity ...

Yangyang Feng, Ming Zhao, Lijian Wang, Ling Li, Josh Haipeng Lei… in Cell Death & Disease (2024)