24 Result(s)

Article

Personal characteristics related to the risk of adolescent internet addiction: a survey in Shanghai, China

Paralleling the rapid growth in computers and internet connections, adolescent internet addiction (AIA) is becoming an increasingly serious problem, especially in develo** countries. This study aims to explo...

Jian Xu, Li-xiao Shen, Chong-huai Yan, Howard Hu, Fang Yang, Lu Wang… in BMC Public Health (2012)

Article

Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study

Coagulation and fibrinolysis activation is frequently observed in cancer patients, and the tumors in these cases are thought to be associated with a higher risk of invasion, metastasis, and worse long-term out...

Yi-Jun Shu, Hao Weng, Run-Fa Bao, **ang-Song Wu, Qian Ding, Yang Cao… in BMC Cancer (2014)

Article

Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling

The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apoli...

Hai-Yan **, Lai-Jiang Chen, Zhen-Zhou Zhang… in Journal of Translational Medicine (2015)

Article

Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015

A1 Hope and despair in the current treatment of nasopharyngeal cancer

IB Tan, Ellen T. Chang, Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien… in BMC Proceedings (2016)

Article

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng… in Journal of Translational Medicine (2017)

Article

Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study

Laparoscopic surgery, fast-track perioperative treatment and XELOX chemotherapy are effective strategies for shortening the duration of hospital stay for cancer patients. This trial aimed to clarify the safety...

Jun Li, **ang-**ng Kong, Jiao-Jiao Zhou, Yong-Mao Song, Xue-Feng Huang… in BMC Cancer (2019)

Article

Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples

COVID-19 (coronavirus disease 2019) has caused a major epidemic worldwide; however, much is yet to be known about the epidemiology and evolution of the virus partly due to the scarcity of full-length SARS-CoV-...

Minfeng **ao, **aoqing Liu, **gkai Ji, Min Li, Jiandong Li, Lin Yang… in Genome Medicine (2020)

Article

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the A...

Jun Wang, Bin-Lu Sun, Yang **ang, Ding-Yuan Tian, Chi Zhu… in Translational Psychiatry (2020)

Article

C/EBPβ promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer

PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency in HR-proficient cancers...

Jiahong Tan, Xu Zheng, Mengchen Li, Fei Ye, Chunyan Song, Cheng Xu… in Oncogene (2021)

Article

Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interv...

**aofen Ruan, Yi** Li, Yuanlong Sun, Meijun Jia, **aowen Xu, Li Huo, Wei Song… in Trials (2021)

Article

Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-termi...

**ao Fang, Song’en Xu, Yiyue Zhang, ** Xu, Zhibin Huang, Wei Liu… in Leukemia (2021)

Article

Single VHH-directed BCMA CAR-T cells cause remission of relapsed/refractory multiple myeloma

Lu Han, Ji-Shuai Zhang, Jian Zhou, Ke-Shu Zhou, Ben-Ling Xu, Lin-Lin Li… in Leukemia (2021)

Article

Disrupted intrinsic functional brain topology in patients with major depressive disorder

Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...

Hong Yang, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Molecular Psychiatry (2021)

Article

Radiomic analysis for predicting prognosis of colorectal cancer from preoperative ¹⁸F-FDG PET/CT

To develop and validate a survival model with clinico-biological features and ¹⁸F- FDG PET/CT radiomic features via machine learning, and for predicting the prognosis from the primary tumor of colorectal cancer.

Lilang Lv, Bowen **n, Yichao Hao, Ziyi Yang, Junyan Xu… in Journal of Translational Medicine (2022)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)

Article

Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype

Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the understanding of non-genetic variation provides a new perspective to study the heterogenei...

Xuming Song, Te Zhang, Hanlin Ding, Yipeng Feng, Wenmin Yang, Xuewen Yin… in Oncogenesis (2022)

Article

Spatiotemporal trends and ecological determinants of cardiovascular mortality among 2844 counties in mainland China, 2006–2020: a Bayesian modeling study of national mortality registries

Cardiovascular disease (CVD) is the leading cause of death in China. No previous study has reported CVD mortality at county-level, and little was known about the nonmedical ecological factors of CVD mortality ...

Wei Wang, Junming Li, Yunning Liu, Pengpeng Ye, Chengdong Xu, Peng Yin… in BMC Medicine (2022)

Article

Noninvasive prediction of axillary lymph node status in breast cancer using promoter profiling of circulating cell-free DNA

Lymph node metastasis (LNM) is one of the most important factors affecting the prognosis of breast cancer. The accurate evaluation of lymph node status is useful to predict the outcomes of patients and guide t...

Zhi-Wei Guo, Qing Liu, Xu Yang, Geng-** Cai… in Journal of Translational Medicine (2022)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for cancers. The growing interest in this ar...

Rexiati Ruze, Jianlu Song, **npeng Yin… in Signal Transduction and Targeted Therapy (2023)