13 Result(s)

Article

Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars

Lychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar ‘Feizixiao’ was assembled into 15 pseudochromosomes, totaling ~470 Mb. High heterozygosity (2.27%) resulted in two complete hap...

Guibing Hu, Junting Feng, Xu **ang, Jiabao Wang, Jarkko Salojärvi… in Nature Genetics (2022)

Article

Brief report of the first cured 2019-nCoV pneumonia patient in West China Hospital

En-Qiang Chen, Li-Chun Wang, Guang-Min Tang… in European Journal of Clinical Microbiology … (2020)

Article

Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway

Fulminant liver failure (FHF) is a serious clinical problem and liver transplantation is the major intervention. But the overall survival rate of FHF is low owing to the donated organ shortage. Apolipoprotein ...

Ya-Chao Tao, Meng-Lan Wang, Dong-Bo Wu, Chen Luo… in Journal of Translational Medicine (2019)

Article

Satisfactory virological response and fibrosis improvement of sofosbuvir-based regimens for Chinese patients with hepatitis C virus genotype 3 infection: results of a real-world cohort study

Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patie...

Ya-Chao Tao, Rong Deng, Meng-Lan Wang, Duo-Duo Lv, Man Yuan… in Virology Journal (2018)

Article

The truncated mutant HBsAg expression increases the tumorigenesis of hepatitis B virus by regulating TGF-β/Smad signaling pathway

It has been reported that the emergence of HBV rtA181T/sW172* mutant could result in a dominant secretion defect of HBsAg and increase the risk of HCC development. This study was designed to reveal the role an...

Meng-Lan Wang, Dong-Bo Wu, Ya-Chao Tao, Lan-Lan Chen, Cui-** Liu… in Virology Journal (2018)

Article

Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas

N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor suppressor in lung cancer and explored its molecular mech...

**gshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang… in Molecular Cancer (2017)

Article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

G. Todd Milne, Peter Sandner, Kathleen A. Lincoln… in BMC Pharmacology and Toxicology (2017)

Article

2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,...

** Zhang, Li-na Zhang, Dong-mei Chen, Yan-yun Fu, Feng Zhang… in Acta Pharmacologica Sinica (2015)

Article

Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Nat. Genet. 42, 759–763 (2010); published online 22 August 2010; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors now find no evidence to support...

Li-Dong Wang, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, **n Song, Yan **… in Nature Genetics (2014)

Article

Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation

To investigate the action of isothiafludine (NZ-4), a derivative of bis-heterocycle tandem pairs from the natural product leucamide A, on the replication cycle of hepatitis B virus (HBV) in vitro and in vivo.

Li Yang, Li-** Shi, Hai-jun Chen, **an-Kun Tong… in Acta Pharmacologica Sinica (2014)

Article

Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study

Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colo...

Jonathan N Hofmann, Linda M Liao, Paul T Strickland, **ao-Ou Shu, Gong Yang… in BMC Cancer (2013)

Article

Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy

To investigate the drug interactions between ilaprazole, a new proton pump inhibitor, and clarithromycin following ilaprazole, clarithromycin and amoxicillin combination therapy.

Shan Cao, Gan Zhou, Dong-sheng Ou-YANG, Hui-zi Wu, Kui **ao… in Acta Pharmacologica Sinica (2012)

Article

Nitrofen suppresses cell proliferation and promotes mitochondria-mediated apoptosis in type II pneumocytes

To characterize the molecular mechanisms of nitrofen-induced pulmonary hypoplasia.

Qiang-song Tong, Li-duan Zheng, Shao-tao Tang, Guo-song Jiang… in Acta Pharmacologica Sinica (2007)