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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Article
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models
Autophagy impairment is a key factor in Alzheimer’s disease (AD) pathogenesis. TFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM enhancer 3) are nuclear transcription factors that r...
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Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Article
Open AccessAn improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion
The colloidal borescope, using colloidal particle motion, is used to monitor the flow velocities and directions of groundwater. It integrates advanced techniques such as microscopy, high-speed photography, and...
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Article
Open AccessSalidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation
To investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular network mechanism in diabetic retinapathy (DR) rats.
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Article
Open AccessDiagnostic status and epidemiological characteristics of community-acquired bacterial meningitis in children from 2019 to 2020: a multicenter retrospective study
Community-acquired bacterial meningitis (CABM) is the main cause of morbidity and mortality in children. The epidemiology of CABM is regional and highly dynamic. To clarify the diagnostic status and epidemiolo...
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Chapter and Conference Paper
Evaluation and Optimization of Production Performance for Fractured Buried Hill Reservoir
The C Block of a buried hill reservoir in West Africa exhibits typical dual-porosity characteristics with well-developed natural fractures and a tight matrix. The depletion production was initially employed fo...
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Article
Ferroelectric transistors based on shear-transformation-mediated rhombohedral-stacked molybdenum disulfide
To develop low-power, non-volatile computing-in-memory device using ferroelectric transistor technologies, ferroelectric channel materials with scaled thicknesses are required. Two-dimensional semiconductors, ...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Camellia perpetua has the excellent characteristic of flowering multiple times throughout the year, which is of great importance to solve the problem of “short flowering period” and “low fresh flower yield” in t...
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Article
Open AccessSTCF conceptual design report (Volume 1): Physics & detector
The super τ-charm facility (STCF) is an electron–positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak lumino...
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Article
Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study
Current guidelines discourage the use of direct-acting antiviral (DAA) containing protease-inhibitor (PI) in advanced HCV cirrhosis. We aimed to compare the real-world tolerability of PI vs. non-PI DAA regimen...
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Article
PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer’s Disease Defects By Inducing Autophagy in Mice Models
The autophagy-lysosomal pathway (ALP) is a major cellular machinery involved in the clearance of aggregated proteins in Alzheimer disease (AD). However, ALP is dramatically impaired during AD pathogenesis via ...
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Article
Open AccessA parabrachial-hypothalamic parallel circuit governs cold defense in mice
Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lat...
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Article
Analysis of cuproptosis-related lncRNA signature for predicting prognosis and tumor immune microenvironment in pancreatic cancer
Pancreatic cancer (PC) is a highly malignant digestive tract tumor, with a dismal 5-year survival rate. Recently, cuproptosis was found to be copper-dependent cell death. This work aims to establish a cupropto...
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Article
Open AccessImpact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB
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Article
Open AccessImpaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant
Auditory neuropathy spectrum disorder (ANSD) is a hearing impairment caused by dysfunction of inner hair cells, ribbon synapses, spiral ganglion neurons and/or the auditory nerve itself. Approximately 1/7000 n...
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Article
Open AccessComparison and fusion prediction model for lung adenocarcinoma with micropapillary and solid pattern using clinicoradiographic, radiomics and deep learning features
To investigate whether the combination scheme of deep learning score (DL-score) and radiomics can improve preoperative diagnosis in the presence of micropapillary/solid (MPP/SOL) patterns in lung adenocarcinom...
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Article
Modeling the Operating Performance of a Drinking Water Biological Aerated Filter and the Formation of Organic Nitrogen
In this study, simultaneous storage and growth mechanism, as well as the formation processes of organic nitrogen (ON), were both introduced into activated sludge model 3 (ASM3), and ASM3-ON was formed to predi...
