26 Result(s)

Article

Overexpression of fibrinogen-like protein 2 induces epithelial-to-mesenchymal transition and promotes tumor progression in colorectal carcinoma

The main cause of death in colorectal carcinoma (CRC) patients is tumor metastasis; however, the underlying molecular mechanisms are largely unknown. In the present study, a novel metastasis-related gene, fi...

Wen-Zheng Qin, Quan-Lin Li, Wei-Feng Chen, Mei-Dong Xu, Yi-Qun Zhang… in Medical Oncology (2014)

Article

Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial

Delirium is a common complication in elderly patients after surgery and associated with increased morbidity and mortality. Studies suggest that deep anesthesia and intense pain are important precipitating fact...

Ya-Wei Li, Hui-Juan Li, Huai-** Li, Yi Feng, Yao Yu, **ang-Yang Guo… in BMC Anesthesiology (2015)

Article

Prognostic factors for severe Pneumocystis jiroveci pneumonia of non-HIV patients in intensive care unit: a bicentric retrospective study

Pneumocystis jiroveci pneumonia (PJP) in non-HIV patients is still a challenge for intensivists. The aim of our study was to evaluate mortality predictors of PJP patients requiring Intensive care unit (ICU) admis...

Li Weng, Xu Huang, Lie Chen, Li-Qin Feng, Wei Jiang, **ao-Yun Hu… in BMC Infectious Diseases (2016)

Article

Combination of intramedullary rod, wrap** bone grafting and Ilizarov’s fixator for the treatment of Crawford type IV congenital pseudarthrosis of the tibia: mid-term follow up of 56 cases

The purpose of this study was to investigate the initial union rate, refracture rate and residual deformities of congenital pseudarthrosis of the tibia (CPT), using combined surgery including pseudarthrosis re...

Guang-hui Zhu, Hai-bo Mei, Rong-guo He, Yao-xi Liu… in BMC Musculoskeletal Disorders (2016)

Article

The combination of cantharidin and antiangiogenic therapeutics presents additive antitumor effects against pancreatic cancer

Cantharidin, one of the active components of mylabris, is believed to have antitumor activity. Cantharidin selectively inhibits protein phosphatase 2A (PP2A), which can repress multiple oncogenic kinases (ERK,...

Meng-Dan Xu, Lu Liu, Meng-Yao Wu, Min Jiang, Liu-Mei Shou, Wen-Jie Wang… in Oncogenesis (2018)

Article

Continuous intravenous infusion of remifentanil improves the experience of parturient undergoing repeated cesarean section under epidural anesthesia, a prospective, randomized study

Unsatisfactory analgesia would occur frequently during repeated cesarean section under epidural anesthesia. The aim of this study is to observe the effects of intravenous remifentanil on maternal comfort, mate...

Wei Yan, Yun **ong, Yu Yao, Feng-jiang Zhang, Li-na Yu, Min Yan in BMC Anesthesiology (2019)

Article

Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue

Huan-**n Chen, Ming-Yang Li, Yi-Yao Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant

Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain un...

Cheng Zhang, **ao-Qi Wang, Rong-Li Zhang, Fang Liu, Yi Wang, Zhi-Ling Yan… in Leukemia (2021)

Article

A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline

Alzheimer’s disease (AD) is characterized by progressive synaptic dysfunction, neuronal death, and brain atrophy, with amyloid-β (Aβ) plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumula...

Rongcan Luo, Yu Fan, **g Yang, Maosen Ye… in Signal Transduction and Targeted Therapy (2021)

Article

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu… in Signal Transduction and Targeted Therapy (2021)

Article

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

Platelet-derived growth subunit A (PDGFA) plays critical roles in development of glioblastoma (GBM) with substantial evidence from TCGA database analyses and in vivo mouse models. So far, only platelet-derived...

Qu-**g Gai, Zhen Fu, Jiang He, Min Mao… in Signal Transduction and Targeted Therapy (2022)

Article

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

An epidemic of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. SARS-CoV-2 relies on its spike protein to invade host cells by interacting with the human...

Lin Wang, Yan Wu, Sheng Yao, Huan Ge, Ya Zhu, Kun Chen… in Acta Pharmacologica Sinica (2022)

Article

Elevated N-terminal pro C-type natriuretic peptide is associated with mortality in patients undergoing transcatheter aortic valve replacement

Unlike N-terminal pro-B-type natriuretic peptide (NT-proBNP), which have been extensively studied, little is known about the role of N-terminal pro-C-type natriuretic peptide (NT-proCNP) for predicting surviva...

Po Hu, Han Chen, Li-Han Wang, Ju-Bo Jiang, Jia-Min Li… in BMC Cardiovascular Disorders (2022)