23 Result(s)

Article

Idebenone Antagonizes P53-Mediated Neuronal Oxidative Stress Injury by Regulating CD38-SIRT3 Protein Level

Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD...

Hao Xu, Ying Guo, **ao-Jun Liu, Ying Liu, Shi Yin, Qi-Ying Bao… in Neurochemical Research (2024)

Article

Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish

Purinergic receptor P2Y11, a G protein-coupled receptor that is stimulated by extracellular ATP, has been demonstrated to be related to the chemotaxis of granulocytes, apoptosis of neutrophils, and secretion o...

Lin Zhao, Li-feng Wang, Yi-chen Wang, Ao Liu, Qian-wen **ao… in Cell Biology and Toxicology (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

YAP1 expression is associated with survival and immunosuppression in small cell lung cancer

Immunotherapy is considered a major breakthrough in the treatment of small cell lung cancer (SCLC), although its anti-tumor efficacy is limited. With a high degree of malignancy and high heterogeneity, SCLC is...

Peixin Chen, Chenglong Sun, Hao Wang, Wencheng Zhao, Yan Wu… in Cell Death & Disease (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Osteocalcin ameliorates cognitive dysfunctions in a mouse model of Alzheimer’s Disease by reducing amyloid β burden and upregulating glycolysis in neuroglia

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by the accumulation of amyloid β peptides (Aβ) and impaired glucose metabolism in the brain. Osteocalcin (OCN), an osteoblast...

Chang Shan, Deng Zhang, Dong-ni Ma, Yan-fang Hou, Qian-qian Zhuang… in Cell Death Discovery (2023)

Article

E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING

Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase which is expressed in a variety of human tissues. RNF5 is involved in the regulation of endoplasmic reticulum stress, inflammation, and innate immunity an...

Lu-Lu Yang, Wen-Chang **ao, Huan Li, Zheng-Yang Hao, Gui-Zhi Liu… in Cell Death & Disease (2022)

Article

Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury

Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in p...

Fei Yao, Yang Luo, Yan-Chang Liu, Yi-Hao Chen, Yi-Teng Li… in Inflammation and Regeneration (2022)

Article

Correction to: BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

**g-zun Xu, Yan-man Zhou, Lin-lin Zhang, **ao-**g Chen… in Cell Death Discovery (2022)

Article

Correction: FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathways

Yan-Feng Huang, Wen-Bo Niu, Rong Hu, Ling-Jun Wang, Zeng-Yan Huang… in Oncogenesis (2022)

Article

BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

Age-related osteoporosis is characterized by the accumulation of senescent osteoblastic cells in bone microenvironment and significantly reduced osteogenic differentiation. Clearing of the senescent cells is h...

**g-zun Xu, Yan-man Zhou, Lin-lin Zhang, **ao-**g Chen… in Cell Death Discovery (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Her...

Zhen Wang, Fan-lian Zeng, Ya-wen Hu… in Signal Transduction and Targeted Therapy (2022)

Article

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway

Serum response factor (SRF) regulates differentiation and proliferation by binding to RhoA-actin-activated MKL or Ras-MAPK-activated ELK transcriptional coactivators, but the molecular mechanisms responsible f...

Shang-Ze Li, Ze-Yan Zhang, Jie Chen, Ming-You Dong, Xue-Hua Du… in Cell Death Discovery (2022)

Article

Author Correction: 863 genomes reveal the origin and domestication of chicken

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Ming-Shan Wang, Mukesh Thakur, Min-Sheng Peng, Yu Jiang… in Cell Research (2020)

Article

863 genomes reveal the origin and domestication of chicken

Despite the substantial role that chickens have played in human societies across the world, both the geographic and temporal origins of their domestication remain controversial. To address this issue, we analy...

Ming-Shan Wang, Mukesh Thakur, Min-Sheng Peng, Yu Jiang… in Cell Research (2020)

Article

Suppressing microRNA-29c promotes biliary atresia-related fibrosis by targeting DNMT3A and DNMT3B

This study was designed to investigate the potential role of microRNA-29c (miR-29c) in biliary atresia-related fibrosis. The expression of miR-29c was determined in 15 pairs of peripheral blood samples from in...

Jian-yao Wang, Hao Cheng, Hong-yan Zhang… in Cellular & Molecular Biology Letters (2019)

Article

FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathways

Colorectal cancer stem cells (CSCs), characterized by self-renewal ability and high expression of proliferative genes, contribute to the chemoresistance of colorectal cancer (CRC). We aimed to identify the mol...

Yan-Feng Huang, Wen-Bo Niu, Rong Hu, Ling-Jun Wang, Zeng-Yan Huang… in Oncogenesis (2018)

Article

The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis

The abnormal expression of microRNAs (miRNAs) in colorectal cancer (CRC) progression has been widely investigated. It was reported that the same hairpin RNA structure could generate mature products from each s...

Lin-Lin Ren, Ting-Ting Yan, Chao-Qin Shen, Jia-Yin Tang, Xuan Kong… in Cell Death & Disease (2018)

Article

Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natura...

Ying-Ya Cao, **g Yu, Ting-Ting Liu, Kai-**a Yang, Li-Yan Yang… in Cell Death & Disease (2018)