30 Result(s)
within
**g-Wen Su
Life Sciences
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Article
Open AccessDUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...
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Open AccessIdentification of NADPH Oxidase Genes Crucial for Rice Multiple Disease Resistance and Yield Traits
Reactive oxygen species (ROS) act as a group of signaling molecules in rice functioning in regulation of development and stress responses. Respiratory burst oxidase homologues (Rbohs) are key enzymes in genera...
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Identification of potential genetic causal variants for obesity-related traits using statistical fine map**
Obesity is highly influenced by heritability and variant effects. While previous genome-wide association studies (GWASs) have successfully identified numerous genetic loci associated with obesity-related trait...
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Open AccessSurvival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways
Pan-cancer studies have disclosed many commonalities and differences in mutations, copy number variations, and gene expression alterations among cancers. Some of these features are significantly associated wit...
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Open AccessExosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4
Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-...
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Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes
Epidermal differentiation and barrier function require well-controlled matriptase and prostasin proteolysis, in which the Kunitz-type serine protease inhibitor HAI-1 represents the primary enzymatic inhibitor ...
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Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species (Oryza rufipogon and O. nivara)
It is of critical importance for our understanding of speciation process to determine the forms of reproductive isolation and their relative importance in species divergence. Oryza nivara and O. rufipogon are dir...
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Open AccessExcess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy
When stressed, eukaryotic cells produce triacylglycerol (TAG) to store nutrients and mobilize autophagy to combat internal damage. We and others previously reported that in yeast, elimination of TAG synthesizi...
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Open AccessQuantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis
Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We develope...
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Article
Open AccessFreshwater Sordariomycetes
Sordariomycetes is one of the largest classes of Ascomycota that comprises a highly diverse range of fungi mainly characterized by perithecial ascomata and inoperculate unitunicate asci. Freshwater Sordariomyc...
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Article
Open AccessPleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population
Hepatic lipase (HL, encoded by LIPC) is a glycoprotein primarily synthesized and secreted by hepatocytes. Previous studies had demonstrated that HL is crucial for reverse cholesterol transport and affects the met...
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Article
Morphology and multigene phylogeny reveal new genus and species of Torulaceae from freshwater habitats in northwestern Yunnan, China
Current investigations on taxonomy of lignicolous freshwater fungi in northwestern Yunnan, China, have led to the discovery of new fungal species and records that belong to the family Torulaceae. In this paper...
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Morphological and molecular taxonomy of novel species Pleurotheciaceae from freshwater habitats in Yunnan, China
The diversity of lignicolous freshwater fungi of the Greater Mekong Subregion are currently being studied. In this paper, 18 fresh collections of Pleurotheciaceae from submerged wood in freshwater are characteriz...
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Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer
Epidemiological and clinical evidences have shown that bone mineral density (BMD) has a close relationship with breast cancer (BC). They might potentially have a shared genetic basis. By incorporating informat...
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Mechanical evaluation for laminated bamboo lumber along two eccentric compression directions
To evaluate the mechanical performance under two eccentric compression directions, 80 laminated bamboo lumber (LBL) column specimens were tested and analysed. Mechanical properties along two directions were co...
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Open AccessInteractive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population
Apolipoprotein E (APOE) plays a major role in lipid metabolism and inflammation. However, the association between APOE gene polymorphisms and serum triglyceride levels remains controversial. We tested the effects...
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Article
The soybean gene, GmMYBJ2, encodes a R2R3-type transcription factor involved in drought stress tolerance in Arabidopsis thaliana
MYB genes are extensively distributed in higher plants and constitute one of the largest transcription factors (TFs) families. These TFs have been proved to be implicated in the regulatio...
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The modified rice αAmy8 promoter confers high-level foreign gene expression in a novel hypoxia-inducible expression system in transgenic rice seedlings
Expression of α-amylase genes in rice is induced not only by sugar starvation and gibberellin (GA) but also by O2 deficiency. Promoters of two rice α-amylase genes, αAmy3 and αAmy8, have been shown to direct high...
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Recurrent mutations at C-reactive protein gene promoter SNP position −286 in human cancers
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Open AccessPrediction of nuclear proteins using nuclear translocation signals proposed by probabilistic latent semantic indexing
Identification of subcellular localization in proteins is crucial to elucidate cellular processes and molecular functions in a cell. However, given a tremendous amount of sequence data generated in the post-ge...
