222 Result(s)
within
**g Yu Liu
Cell Biology
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Open AccessOtud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway
Pulmonary hypertension (PAH) is a cardiopulmonary disease in which pulmonary artery pressure continues to rise, leading to right heart failure and death. Otud6b is a member of the ubiquitin family and is invol...
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Noninvasive Deep Brain Stimulation via Temporal Interference Electric Fields Enhanced Motor Performance of Mice and Its Neuroplasticity Mechanisms
A noninvasive deep brain stimulation via temporal interference (TI) electric fields is a novel neuromodulation technology, but few advances about TI stimulation effectiveness and mechanisms have been reported....
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Open AccessAn association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells
To elucidate the mechanism of dysfunction of tolerogenic dendritic cells (DCs) is of significance. Telomerase involves the regulation of the cell fate and activities. The objective of this study is to investig...
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Open AccessCirculating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients
Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of develo** recurrence and secondary cancers. This study evaluates the prognostic and surveillance utilities of circulating tumo...
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Open AccessAuthor Correction: Identification of an intraocular microbiota
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Open AccessUSP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy
Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...
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A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells
Breast cancer, the most prevalent malignancy in women, often progresses to bone metastases, especially in older individuals. Dormancy, a critical aspect of bone-metastasized breast cancer cells (BCCs), enables...
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Biological characteristics of Cordyceps militaris single mating-type strains
Cordyceps militaris has been extensively cultivated as a model cordyceps species for commercial purposes. Nevertheless, the problems related to strain degeneration and breeding technologies remain unresolved. Thi...
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Open AccessIdentification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia
Aberrant remodeling of uterine spiral arteries (SPA) is strongly associated with the pathogenesis of early-onset preeclampsia (EOPE). However, the complexities of SPA transformation remain inadequately underst...
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Micropolarity governs the structural organization of biomolecular condensates
Membraneless organelles within cells have unique microenvironments that play a critical role in their functions. However, how microenvironments of biomolecular condensates affect their structure and function r...
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Circ-Bptf Ameliorates Learning and Memory Impairments via the miR-138-5p/p62 Axis in APP/PS1 Mice
Alzheimer's disease (AD) is a common age-associated progressive neurodegenerative disorder that is implicated in the aberrant regulation of numerous circular RNAs (circRNAs). Here, we reported that circ-Bptf, ...
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Open AccessCorrection: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
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Open AccessCorrection: Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns
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Open AccessMultiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns
Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in metastatic PanNETs were not ...
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Open AccessApplication status and optimization suggestions of tumor organoids and CAR-T cell co-culture models
Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and specific marker expression profiles to those of primary tumour...
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Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer
WEE1 and CHEK1 (CHK1) kinases are critical regulators of the G2/M cell cycle checkpoint and DNA damage response pathways. The WEE1 inhibitor AZD1775 and the CHK1 inhibitor SRA737 are in clinical trials for var...
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Open AccessKEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immun...
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Assembly and characterization of the complete mitochondrial genome of Ventilago leiocarpa
We reported the mitochondrial genome of Ventilago leiocarpa for the first time. Two and one sites lead to the generation of stop and stat codon through editing were verified.
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Open AccessMelanoma biology and treatment: a review of novel regulated cell death-based approaches
The incidence of melanoma, the most lethal form of skin cancer, has increased due to ultraviolet exposure. The treatment of advanced melanoma, particularly metastatic cases, remains challenging with poor outco...
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Open AccessMyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver diseases and has emerged as the leading factor in the pathogenesis of hepatocellular carcinoma (HCC). MyD88 contributes to the develop...
