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Open AccessInflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC
Inflammasome activity is important for the immune response and is instrumental in numerous clinical conditions. Here we identify a mechanism that modulates the central Caspase-1 and NLR (Nod-like receptor) ada...
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Open AccessA scATAC-seq atlas of chromatin accessibility in axolotl brain regions
Axolotl (Ambystoma mexicanum) is an excellent model for investigating regeneration, the interaction between regenerative and developmental processes, comparative genomics, and evolution. The brain, which serves a...
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Open AccessAuthor Correction: SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish
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Open AccessAltered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration
There are major differences in duration and scale at which limb development and regeneration proceed, raising the question to what extent regeneration is a recapitulation of development. We address this by ana...
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Open AccessConstruction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution
The Mexican axolotl (Ambystoma mexicanum) is a well-established tetrapod model for regeneration and developmental studies. Remarkably, neotenic axolotls may undergo metamorphosis, a process that triggers many dra...
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Article
Open AccessSpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish
Precise genetic modifications in model organisms are essential for biomedical research. The recent development of PAM-less base editors makes it possible to assess the functional impact and pathogenicity of nu...
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Retraction Note: Overexpression of CAV3 facilitates bone formation via the Wnt signaling pathway in osteoporotic rats
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Open AccessSerum ErbB2 concentration positively correlated to the glycemic variations in newly diagnosed Type 2 diabetic patients
Evidences indicate that elevated levels of circulating ErbB2 are closely associated with increased incidence of diabetes. However, the relationship between ErbB2 concentration and glycemic variations (GV) in t...
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Correction to: Overexpression of CAV3 facilitates bone formation via the Wnt signaling pathway in osteoporotic rats
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessAuthor Correction: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessProline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse
Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks ...
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Open AccessGlycemic variation in uncontrolled Graves’ disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring
To observe the glycemic variation (GV) in uncontrolled Graves’ disease (GD) patients with normal glucose metabolism measured by continuous glucose monitoring (CGM).
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Author Correction: The axolotl genome and the evolution of key tissue formation regulators
In the originally published version of this Article, the sequenced axolotl strain (the homozygous white mutant) was denoted as ‘D/D’ rather than ‘d/d’ in Fig. 1a and the accompanying legend, the main text and ...
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Open AccessMetformin add-on continuous subcutaneous insulin infusion on precise insulin doses in patients with type 2 diabetes
To investigate whether metformin add-on to the continuous subcutaneous insulin infusion (Met + CSII) therapy leads to a significant reduction in insulin doses required by type 2 diabetes (T2D) patients to main...
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Open AccessManagement of glycemic variation in diabetic patients receiving parenteral nutrition by continuous subcutaneous insulin infusion (CSII) therapy
To compare the continuous subcutaneous insulin infusion (CSII) or insulin glargine based multiple injections (MDI) therapy on glycemic variations in diabetic patients receiving PN outside of intensive care set...
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Article
Open AccessThe axolotl genome and the evolution of key tissue formation regulators
Salamanders serve as important tetrapod models for developmental, regeneration and evolutionary studies. An extensive molecular toolkit makes the Mexican axolotl (Ambystoma mexicanum) a key representative salaman...
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Article
Open AccessYoung onset type 2 diabetic patients might be more sensitive to metformin compared to late onset type 2 diabetic patients
It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data ...
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Open AccessCorrection: Corrigendum: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
Nature Communications 7: Article number: 13045 (2016); Published: 10 October 2016; Updated: 14 June 2017 This Article contains an error in Fig. 8a, for which we apologize. In Fig. 8a, the control 3 image for p...
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Open AccessImproving Spatiotemporal Breast Cancer Assessment and Prediction in Hangzhou City, China
Breast cancer (BC) is the main cause of death of female cancer patients in China. Mainstream map** techniques, like spatiotemporal ordinary kriging (STOK), generate disease incidence maps that improve our un...
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Open AccessFeatures of glycemic variations in drug naïve type 2 diabetic patients with different HbA1c values
To define the features of glycemic variations in drug naïve type 2 diabetic (T2D) patients with different HbA1c values using continuous glucose monitoring (CGM), a total of 195 drug naïve T2D patients were admitt...