11 Result(s)
within
**fang Xue
Biomedicine
-
Article
Open AccessTelomere-to-telomere Citrullus super-pangenome provides direction for watermelon breeding
To decipher the genetic diversity within the cucurbit genus Citrullus, we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven Citrullus species. This T2T super-pangeno...
-
Article
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy
Amanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death....
-
Article
Mechanism and treatment of α-amanitin poisoning
Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symp...
-
Article
Selecting Multiple Node Statistics Jointly from Functional Connectivity Networks for Brain Disorders Identification
Functional connectivity networks (FCN) analysis is instructive for the diagnosis of brain diseases, such as mild cognitive impairment (MCI) and major depressive disorder (MDD) at their early stages. As the cri...
-
Article
Review: the role of GSDMD in sepsis
Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell de...
-
Article
Open AccessOptimizing the timing of diagnostic testing after positive findings in lung cancer screening: a proof of concept radiomics study
The timeliness of diagnostic testing after positive screening remains suboptimal because of limited evidence and methodology, leading to delayed diagnosis of lung cancer and over-examination. We propose a radi...
-
Article
Open AccessIs exposure to tobacco associated with extrahepatic cholangiocarcinoma epidemics? A retrospective proportional mortality study in China
Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this stu...
-
Article
Open AccessChallenges and research opportunities for lung cancer screening in China
Following publication of the results of the National Lung Screening Trial in the United States, a randomized controlled trial in Italy (ITALUNG) and two simulation studies in China reported similar findings in...
-
Article
Open AccessMortality outcomes of low-dose computed tomography screening for lung cancer in urban China: a decision analysis and implications for practice
Mortality outcomes in trials of low-dose computed tomography (CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer ...
-
Article
Effect Comparison of Both Iron Chelators on Outcomes, Iron Deposit, and Iron Transporters After Intracerebral Hemorrhage in Rats
Iron overload plays a key role in brain injury after intracerebral hemorrhage (ICH). We explored the roles of ferric iron chelator—deferiprone (DFP)—and ferrous iron chelator—clioquinol (CQ)—in ICH rats throug...
-
Article
Effects of active, passive, and combined smoking on cervical cancer mortality: a nationwide proportional mortality study in Chinese urban women
To determine whether smoking, in any form, is a risk factor in the development of cervical cancer (CC) among urban Chinese women.
